Protein PA4608

From Proteopedia

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(as it appears on PubMed at http://www.pubmed.gov), where 17096419 is the PubMed ID number.
(as it appears on PubMed at http://www.pubmed.gov), where 17096419 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17096419}}
 
<scene name='1ywu/Chain/2'>Chain</scene>
<scene name='1ywu/Chain/2'>Chain</scene>
<scene name='1ywu/Bindingsite/3'>C-di-GMP binding site</scene>
<scene name='1ywu/Bindingsite/3'>C-di-GMP binding site</scene>
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==PA4608 PilZ domain==
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<scene name='1ywu/Pilz_active/1'>PilZ active site</scene> (R9, R13, D35, S37, G40)
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{{ABSTRACT_PUBMED_17096419}}
==About this Structure==
==About this Structure==
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[[Category: C-di-GMP]]
[[Category: C-di-GMP]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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Created with the participation of [[User:Tilman Schirmer|Tilman Schirmer]].
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==PA4608 PilZ domain==
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<scene name='1ywu/Pilz_active/1'>PilZ active site</scene> (R9, R13, D35, S37, G40)
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Revision as of 10:19, 6 June 2012

Template:STRUCTURE 1ywu

Contents

Solution NMR structure of Pseudomonas Aeruginosa protein PA4608. Northeast Structural Genomics target PaT7

PA4608 PilZ domain

(R9, R13, D35, S37, G40)


Publication Abstract from PubMed

PA4608 is a 125 residue protein from Pseudomonas aeruginosa with a recent identification as a PilZ domain and putative bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) adaptor protein that plays a role in bacterial second-messenger regulated processes. The nuclear magnetic resonance (NMR) structure of PA4608 has been determined and c-di-GMP binding has been confirmed by NMR titration studies. The monomeric core structure of PA4608 contains a six-stranded anti-parallel beta barrel flanked by three helices. Conserved surface residues among PA4608 homologs suggest the c-di-GMP binding site is at one end of the barrel and includes residues in the helices as well as in the unstructured N-terminus. Chemical shift changes in PA4608 resonances upon titration with c-di-GMP confirm binding. This evidence supports the hypothesis that proteins containing PilZ domains are the long-sought c-di-GMP adaptor proteins.

NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein., Ramelot TA, Yee A, Cort JR, Semesi A, Arrowsmith CH, Kennedy MA, Proteins. 2007 Feb 1;66(2):266-71. PMID:17096419

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1YWU is a 1 chain structure of sequence from Pseudomonas aeruginosa pao1. Full experimental information is available from OCA.

Reference

NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein., Ramelot TA, Yee A, Cort JR, Semesi A, Arrowsmith CH, Kennedy MA, Proteins. 2007 Feb 1;66(2):266-71. PMID:17096419
Created with the participation of Tilman Schirmer.

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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