1ywu
From Proteopedia
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Revision as of 10:41, 6 June 2012
Solution NMR structure of Pseudomonas Aeruginosa protein PA4608. Northeast Structural Genomics target PaT7
PA4608 is a 125 residue protein from Pseudomonas aeruginosa with a recent identification as a PilZ domain and putative bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) adaptor protein that plays a role in bacterial second-messenger regulated processes. The nuclear magnetic resonance (NMR) structure of PA4608 has been determined and c-di-GMP binding has been confirmed by NMR titration studies. The monomeric core structure of PA4608 contains a six-stranded anti-parallel beta barrel flanked by three helices. Conserved surface residues among PA4608 homologs suggest the c-di-GMP binding site is at one end of the barrel and includes residues in the helices as well as in the unstructured N-terminus. Chemical shift changes in PA4608 resonances upon titration with c-di-GMP confirm binding. This evidence supports the hypothesis that proteins containing PilZ domains are the long-sought c-di-GMP adaptor proteins.
NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein., Ramelot TA, Yee A, Cort JR, Semesi A, Arrowsmith CH, Kennedy MA, Proteins. 2007 Feb 1;66(2):266-71. PMID:17096419
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1ywu is a 1 chain structure with sequence from Pseudomonas aeruginosa. Full experimental information is available from OCA.
Reference
- Ramelot TA, Yee A, Cort JR, Semesi A, Arrowsmith CH, Kennedy MA. NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein. Proteins. 2007 Feb 1;66(2):266-71. PMID:17096419 doi:10.1002/prot.21199
Categories: Pseudomonas aeruginosa | Arrowsmith, C H. | Cort, J R. | Kennedy, M A. | NESG, Northeast Structural Genomics Consortium. | Ramelot, T A. | Semesi, A. | Yee, A A. | Beta barrel | Nesg | Northeast structural genomics consortium | Pa4608 | Pat7 | Pilz domain | Protein structure initiative | Psi | Structural genomic | Unknown function
