1gnj
From Proteopedia
(New page: 200px<br /> <applet load="1gnj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gnj, resolution 2.60Å" /> '''HUMAN SERUM ALBUMIN...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GNJ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ACD as [[http://en.wikipedia.org/wiki/ligand ligand]]. The following page contains interesting information on the relation of 1GNJ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb37_1.html Serum Albumin]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]]. | + | 1GNJ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ACD as [[http://en.wikipedia.org/wiki/ligand ligand]]. The following page contains interesting information on the relation of 1GNJ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb37_1.html Serum Albumin]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GNJ OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: plasma protein]] | [[Category: plasma protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:22:55 2007'' |
Revision as of 11:18, 30 October 2007
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HUMAN SERUM ALBUMIN COMPLEXED WITH CIS-5,8,11,14-EICOSATETRAENOIC ACID (ARACHIDONIC ACID)
Overview
The primary ligands of human serum albumin (HSA), an abundant plasma, protein, are non-esterified fatty acids. In vivo, the majority of fatty, acids associated with the protein are unsaturated. We present here the, first high-resolution crystal structures of HSA complexed with two, important unsaturated fatty acids, the monounsaturated oleic acid (C18:1), and the polyunsaturated arachidonic acid (C20:4). Both compounds are, observed to occupy the seven binding sites distributed across the protein, that are also bound by medium and long-chain saturated fatty acids., Although C18:1 fatty acid binds each site on HSA in a conformation almost, identical with that of the corresponding saturated compound (C18:0), the, presence of multiple cis double bonds in C20:4 induces distinct binding, ... [(full description)]
About this Structure
1GNJ is a [Single protein] structure of sequence from [Homo sapiens] with ACD as [ligand]. The following page contains interesting information on the relation of 1GNJ with [Serum Albumin]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids., Petitpas I, Grune T, Bhattacharya AA, Curry S, J Mol Biol. 2001 Dec 14;314(5):955-60. PMID:11743713
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