1gni
From Proteopedia
(New page: 200px<br /> <applet load="1gni" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gni, resolution 2.40Å" /> '''HUMAN SERUM ALBUMIN...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GNI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with OLA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GNI OCA]]. | + | 1GNI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with OLA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: OL1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GNI OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: plasma protein]] | [[Category: plasma protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:23:09 2007'' |
Revision as of 11:18, 30 October 2007
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HUMAN SERUM ALBUMIN COMPLEXED WITH CIS-9-OCTADECENOIC ACID (OLEIC ACID)
Overview
The primary ligands of human serum albumin (HSA), an abundant plasma, protein, are non-esterified fatty acids. In vivo, the majority of fatty, acids associated with the protein are unsaturated. We present here the, first high-resolution crystal structures of HSA complexed with two, important unsaturated fatty acids, the monounsaturated oleic acid (C18:1), and the polyunsaturated arachidonic acid (C20:4). Both compounds are, observed to occupy the seven binding sites distributed across the protein, that are also bound by medium and long-chain saturated fatty acids., Although C18:1 fatty acid binds each site on HSA in a conformation almost, identical with that of the corresponding saturated compound (C18:0), the, presence of multiple cis double bonds in C20:4 induces distinct binding, ... [(full description)]
About this Structure
1GNI is a [Single protein] structure of sequence from [Homo sapiens] with OLA as [ligand]. Structure known Active Site: OL1. Full crystallographic information is available from [OCA].
Reference
Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids., Petitpas I, Grune T, Bhattacharya AA, Curry S, J Mol Biol. 2001 Dec 14;314(5):955-60. PMID:11743713
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