1gng
From Proteopedia
(New page: 200px<br /> <applet load="1gng" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gng, resolution 2.60Å" /> '''GLYCOGEN SYNTHASE K...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GNG is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 and TRS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GNG OCA]]. | + | 1GNG is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 and TRS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GNG OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Transferred entry: 2.7.11.1]] | ||
[[Category: Bax, B.]] | [[Category: Bax, B.]] | ||
[[Category: Bridges, A.]] | [[Category: Bridges, A.]] | ||
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[[Category: protein kinase]] | [[Category: protein kinase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:23:24 2007'' |
Revision as of 11:18, 30 October 2007
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GLYCOGEN SYNTHASE KINASE-3 BETA (GSK3) COMPLEX WITH FRATTIDE PEPTIDE
Overview
BACKGROUND: Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates, four serine residues on glycogen synthase (GS), in the sequence, SxxxSxxxSxxx-SxxxS(p), by recognizing and phosphorylating the first serine, in the sequence motif SxxxS(P) (where S(p) represents a phosphoserine)., FRATtide (a peptide derived from a GSK-3 binding protein) binds to GSK-3, and blocks GSK-3 from interacting with Axin. This inhibits the, Axin-dependent phosphorylation of beta-catenin by GSK-3. RESULTS:, Structures of uncomplexed Tyr216 phosphorylated GSK-3beta and of its, complex with a peptide and a sulfate ion both show the activation loop, adopting a conformation similar to that in the phosphorylated and active, forms of the related kinases CDK2 and ERK2. The sulfate ion, adjacent to, Val214 on the ... [(full description)]
About this Structure
1GNG is a [Protein complex] structure of sequences from [Homo sapiens] with SO4 and TRS as [ligands]. Active as [Transferred entry: 2.7.11.1], with EC number [2.7.1.37]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation., Bax B, Carter PS, Lewis C, Guy AR, Bridges A, Tanner R, Pettman G, Mannix C, Culbert AA, Brown MJ, Smith DG, Reith AD, Structure. 2001 Dec;9(12):1143-52. PMID:11738041
Page seeded by OCA on Tue Oct 30 13:23:24 2007
Categories: Homo sapiens | Protein complex | Transferred entry: 2.7.11.1 | Bax, B. | Bridges, A. | Brown, M.J.B. | Carter, P. | Culbert, A.A. | Guy, A.R. | Lewis, C. | Mannix, C. | Pettman, G. | Reith, A.D. | Smith, D.G. | Tanner, R. | SO4 | TRS | Active | Gsk3/frattide complex | Phosphorylated | Protein kinase
