2gf1
From Proteopedia
(New page: 200px<br /> <applet load="2gf1" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gf1" /> '''SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GR...) |
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'''SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR 1: A NUCLEAR MAGNETIC RESONANCE AND RESTRAINED MOLECULAR DYNAMICS STUDY'''<br /> | '''SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR 1: A NUCLEAR MAGNETIC RESONANCE AND RESTRAINED MOLECULAR DYNAMICS STUDY'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2GF1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 2GF1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GF1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: growth factor]] | [[Category: growth factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:27:58 2008'' |
Revision as of 15:27, 15 February 2008
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SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR 1: A NUCLEAR MAGNETIC RESONANCE AND RESTRAINED MOLECULAR DYNAMICS STUDY
Contents |
Overview
The solution structure of human insulin-like growth factor 1 has been, investigated with a combination of nuclear magnetic resonance and, restrained molecular dynamics methods. The results show that the solution, structure is similar to that of insulin, but minor differences exist. The, regions homologous to insulin are well-defined, while the remainder of the, molecule exhibits greater disorder. The resultant structures have been, used to visualize the sites for interaction with a number of, physiologically important proteins.
Disease
Known disease associated with this structure: Growth retardation with deafness and mental retardation due to IGF1 deficiency OMIM:[147440]
About this Structure
2GF1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study., Cooke RM, Harvey TS, Campbell ID, Biochemistry. 1991 Jun 4;30(22):5484-91. PMID:2036417
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