2h9l
From Proteopedia
(New page: 200px<br /> <applet load="2h9l" size="450" color="white" frame="true" align="right" spinBox="true" caption="2h9l, resolution 1.75Å" /> '''WDR5delta23'''<br /...) |
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| - | [[Image:2h9l.gif|left|200px]]<br /> | + | [[Image:2h9l.gif|left|200px]]<br /><applet load="2h9l" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2h9l" size=" | + | |
caption="2h9l, resolution 1.75Å" /> | caption="2h9l, resolution 1.75Å" /> | ||
'''WDR5delta23'''<br /> | '''WDR5delta23'''<br /> | ||
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==Disease== | ==Disease== | ||
| - | Known disease associated with this structure: Asphyxiating thoracic dystrophy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611177 611177]] | + | Known disease associated with this structure: Asphyxiating thoracic dystrophy 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611177 611177]] |
==About this Structure== | ==About this Structure== | ||
| - | 2H9L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2H9L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9L OCA]. |
==Reference== | ==Reference== | ||
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[[Category: wdr5]] | [[Category: wdr5]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:30:35 2008'' |
Revision as of 15:30, 15 February 2008
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WDR5delta23
Contents |
Overview
Histone methylation at specific lysine residues brings about various, downstream events that are mediated by different effector proteins. The, WD40 domain of WDR5 represents a new class of histone methyl-lysine, recognition domains that is important for recruiting H3K4, methyltransferases to K4-dimethylated histone H3 tail as well as for, global and gene-specific K4 trimethylation. Here we report the crystal, structures of full-length WDR5, WDR5Delta23 and its complexes with, unmodified, mono-, di- and trimethylated histone H3K4 peptides. The, structures reveal that WDR5 is able to bind all of these histone H3, peptides, but only H3K4me2 peptide forms extra interactions with WDR5 by, use of both water-mediated hydrogen bonding and the altered hydrophilicity, of the modified lysine 4. We propose a mechanism for the involvement of, WDR5 in binding and presenting histone H3K4 for further methylation as a, component of MLL complexes.
Disease
Known disease associated with this structure: Asphyxiating thoracic dystrophy 2 OMIM:[611177]
About this Structure
2H9L is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structural basis for molecular recognition and presentation of histone H3 by WDR5., Schuetz A, Allali-Hassani A, Martin F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J, EMBO J. 2006 Sep 20;25(18):4245-52. Epub 2006 Aug 31. PMID:16946699
Page seeded by OCA on Fri Feb 15 17:30:35 2008
Categories: Homo sapiens | Single protein | Allali-Hassani, A. | Arrowsmith, C.H. | Bochkarev, A. | Edwards, A.M. | Loppnau, P. | Martin, F. | Min, J.R. | Plotnikov, A.N. | SGC, Structural.Genomics.Consortium. | Schuetz, A. | Sundstrom, M. | Vedadi, M. | Weigelt, J. | SO4 | Sgc | Structural genomics | Structural genomics consortium | Wdr5
