Factor inhibiting HIF
From Proteopedia
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{{STRUCTURE_1mzf| PDB=1mzf | SIZE=400| SCENE= |right|CAPTION=Factor inhibiting HIF complex with oxogluterate derivative, [[1mzf]] }} | {{STRUCTURE_1mzf| PDB=1mzf | SIZE=400| SCENE= |right|CAPTION=Factor inhibiting HIF complex with oxogluterate derivative, [[1mzf]] }} | ||
| - | For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. | + | For details on '''Factor inhibiting HIF''' see [[Molecular Playground/FIH]]. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen. |
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
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== 3D Structures of factor inhibiting HIF == | == 3D Structures of factor inhibiting HIF == | ||
| - | + | ''Update June 2012'' | |
| - | + | [[1mze]], [[1h2n]], [[1iz3]] – hFIH1α – human | |
| - | + | ===FIH1α complex with small molecule=== | |
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| - | + | [[1yci]], [[3od4]], [[2yc0]], [[2yde]]– hFIH1α + inhibitor<br /> | |
| + | [[2w0x]] - hFIH1α + pyridine derivative<br /> | ||
| + | [[2cgn]] – hFIH1α + succinate<br /> | ||
| + | [[2cgo]] – hFIH1α + fumarate<br /> | ||
| + | [[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]] – hFIH1α + oxoglutarate derivative<br /> | ||
| + | [[3kcx]], [[3kcy]], [[3od4]] - hFIH1α + quinol derivative<br /> | ||
| - | [[1h2k]], [[1h2l]], [[1h2m]] – | + | ===FIH1α complex with polypeptide=== |
| - | [[2ilm]], [[3d8c]] - | + | |
| - | [[3p3n]], [[3p3p]] - | + | [[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br /> |
| - | [[2xum]] - | + | [[2ilm]], [[3d8c]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br /> |
| - | [[2y0i]] - | + | [[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br /> |
| + | [[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br /> | ||
| + | [[2y0i]] - hFIH1α + tankyrase 2 peptide<br /> | ||
| + | [[3hqr]], [[3hqu]] - hFIH 1α C terminal + EGL nine homolog<br /> | ||
| + | [[1lqb]], [[1lm8]] - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL<br /> | ||
| + | [[1l3e]] - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR<br /> | ||
| + | [[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger | ||
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| + | ===FIH2α=== | ||
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| + | [[2a24]], [[3f1n]], [[3f1o]], [[3f1p]], [[3h7w]] - hFIH 2α PAS domain + hFIH 1β PAS domain<br /> | ||
| + | [[3h82]] - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant) | ||
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| + | ===FIH1β=== | ||
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| + | [[2b02]], [[1x0o]] - hFIH 1β PAS domain<br /> | ||
| + | [[2hv1]], [[2k7s ]]- hFIH 1β PAS domain - NMR | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:03, 14 June 2012
For details on Factor inhibiting HIF see Molecular Playground/FIH. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen.
Contents |
3D Structures of factor inhibiting HIF
Update June 2012
1mze, 1h2n, 1iz3 – hFIH1α – human
FIH1α complex with small molecule
1yci, 3od4, 2yc0, 2yde– hFIH1α + inhibitor
2w0x - hFIH1α + pyridine derivative
2cgn – hFIH1α + succinate
2cgo – hFIH1α + fumarate
1mzf, 2wa3, 2wa4, 2yc0, 2yde – hFIH1α + oxoglutarate derivative
3kcx, 3kcy, 3od4 - hFIH1α + quinol derivative
FIH1α complex with polypeptide
1h2k, 1h2l, 1h2m – hFIH1α + HIF transactivation domain peptide
2ilm, 3d8c - hFIH1α (mutant) + HIF peptide + α-ketoglutarate
3p3n, 3p3p - hFIH1α + Notch 1 peptide
2xum - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative
2y0i - hFIH1α + tankyrase 2 peptide
3hqr, 3hqu - hFIH 1α C terminal + EGL nine homolog
1lqb, 1lm8 - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL
1l3e - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR
1l8c - hFIH 1α C terminal + CREB-binding protein zinc finger
FIH2α
2a24, 3f1n, 3f1o, 3f1p, 3h7w - hFIH 2α PAS domain + hFIH 1β PAS domain
3h82 - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
FIH1β
2b02, 1x0o - hFIH 1β PAS domain
2hv1, 2k7s - hFIH 1β PAS domain - NMR
