2hiz
From Proteopedia
(New page: 200px<br /> <applet load="2hiz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hiz, resolution 2.500Å" /> '''Crystal Structure ...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2hiz. | + | [[Image:2hiz.jpg|left|200px]]<br /><applet load="2hiz" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2hiz" size=" | + | |
caption="2hiz, resolution 2.500Å" /> | caption="2hiz, resolution 2.500Å" /> | ||
'''Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor'''<br /> | '''Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2HIZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PO4 and LIJ as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http:// | + | 2HIZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=LIJ:'>LIJ</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HIZ OCA]. |
==Reference== | ==Reference== | ||
| Line 24: | Line 23: | ||
[[Category: protein-inhibitor complex]] | [[Category: protein-inhibitor complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:32:25 2008'' |
Revision as of 15:32, 15 February 2008
|
Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor
Overview
We describe a novel series of potent inhibitors of human beta-secretase., These compounds possess the hydroxyethyl amine transition state isostere., A 2.5A crystal structure of inhibitor 32 bound to BACE is provided.
About this Structure
2HIZ is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Memapsin 2, with EC number 3.4.23.46 Full crystallographic information is available from OCA.
Reference
Design of potent inhibitors of human beta-secretase. Part 1., Freskos JN, Fobian YM, Benson TE, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Moon JB, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, Winterrowd G, Bioorg Med Chem Lett. 2007 Jan 1;17(1):73-7. Epub 2006 Oct 4. PMID:17046251
Page seeded by OCA on Fri Feb 15 17:32:25 2008
