2i2r
From Proteopedia
(New page: 200px<br /> <applet load="2i2r" size="450" color="white" frame="true" align="right" spinBox="true" caption="2i2r, resolution 3.35Å" /> '''Crystal structure o...) |
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caption="2i2r, resolution 3.35Å" /> | caption="2i2r, resolution 3.35Å" /> | ||
'''Crystal structure of the KChIP1/Kv4.3 T1 complex'''<br /> | '''Crystal structure of the KChIP1/Kv4.3 T1 complex'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2I2R is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA, ZN and NA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2I2R is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2R OCA]. |
==Reference== | ==Reference== | ||
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[[Category: potassium channel]] | [[Category: potassium channel]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:34:36 2008'' |
Revision as of 15:34, 15 February 2008
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Crystal structure of the KChIP1/Kv4.3 T1 complex
Overview
Brain I(A) and cardiac I(to) currents arise from complexes containing Kv4, voltage-gated potassium channels and cytoplasmic calcium-sensor proteins, (KChIPs). Here, we present X-ray crystallographic and small-angle X-ray, scattering data that show that the KChIP1-Kv4.3 N-terminal cytoplasmic, domain complex is a cross-shaped octamer bearing two principal interaction, sites. Site 1 comprises interactions between a unique Kv4 channel, N-terminal hydrophobic segment and a hydrophobic pocket formed by, displacement of the KChIP H10 helix. Site 2 comprises interactions between, a T1 assembly domain loop and the KChIP H2 helix. Functional and, biochemical studies indicate that site 1 influences channel trafficking, whereas site 2 affects channel gating, and that calcium binding is, intimately linked to KChIP folding and complex formation. Together, the, data resolve how Kv4 channels and KChIPs interact and provide a framework, for understanding how KChIPs modulate Kv4 function.
About this Structure
2I2R is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus with , and as ligands. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer., Pioletti M, Findeisen F, Hura GL, Minor DL Jr, Nat Struct Mol Biol. 2006 Nov;13(11):987-95. Epub 2006 Oct 22. PMID:17057713
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