2ch9
From Proteopedia
(New page: 200px<br /> <applet load="2ch9" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ch9, resolution 2.10Å" /> '''CRYSTAL STRUCTURE O...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2CH9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG, ZN and ACT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CH9 OCA]]. | + | 2CH9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG, ZN and ACT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC6. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CH9 OCA]]. |
==Reference== | ==Reference== | ||
| Line 25: | Line 25: | ||
[[Category: thiol protease inhibitor]] | [[Category: thiol protease inhibitor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:25:08 2007'' |
Revision as of 11:20, 30 October 2007
|
CRYSTAL STRUCTURE OF DIMERIC HUMAN CYSTATIN F
Overview
Cystatins are important natural cysteine protease inhibitors targeting, primarily papain-like cysteine proteases, including cathepsins and, parasitic proteases like cruzipain, but also mammalian asparaginyl, endopeptidase. Mammalian cystatin F, which is expressed almost exclusively, in hematopoietic cells and accumulates in lysosome-like organelles, has, been implicated in the regulation of antigen presentation and other immune, processes. It is an unusual cystatin superfamily member with a, redox-regulated activation mechanism and a restricted specificity profile., We describe the 2.1A crystal structure of human cystatin F in its dimeric, "off" state. The two monomers interact in a fashion not seen before for, cystatins or cystatin-like proteins that is crucially dependent on an, unusual ... [(full description)]
About this Structure
2CH9 is a [Single protein] structure of sequence from [Homo sapiens] with NAG, ZN and ACT as [ligands]. Structure known Active Site: AC6. Full crystallographic information is available from [OCA].
Reference
Structural basis of reduction-dependent activation of human cystatin F., Schuttelkopf AW, Hamilton G, Watts C, van Aalten DM, J Biol Chem. 2006 Jun 16;281(24):16570-5. Epub 2006 Apr 6. PMID:16601115
Page seeded by OCA on Tue Oct 30 13:25:08 2007
