2ibz
From Proteopedia
(New page: 200px<br /> <applet load="2ibz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ibz, resolution 2.3Å" /> '''Yeast Cytochrome BC1...) |
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caption="2ibz, resolution 2.3Å" /> | caption="2ibz, resolution 2.3Å" /> | ||
'''Yeast Cytochrome BC1 Complex with Stigmatellin'''<br /> | '''Yeast Cytochrome BC1 Complex with Stigmatellin'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2IBZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with HEM, FES, UQ6 and SMA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2] Full crystallographic information is available from [http:// | + | 2IBZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=HEM:'>HEM</scene>, <scene name='pdbligand=FES:'>FES</scene>, <scene name='pdbligand=UQ6:'>UQ6</scene> and <scene name='pdbligand=SMA:'>SMA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IBZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: multisubunit membrane protein complex]] | [[Category: multisubunit membrane protein complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:35:51 2008'' |
Revision as of 15:35, 15 February 2008
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Yeast Cytochrome BC1 Complex with Stigmatellin
Overview
We describe in detail the conformations of the inhibitor stigmatellin in, its free form and bound to the ubiquinone-reducing (Q(B)) site of the, reaction center and to the ubiquinol-oxidizing (Q(o)) site of the, cytochrome bc(1) complex. We present here the first structures of a, stereochemically correct stigmatellin in complexes with a bacterial, reaction center and the yeast cytochrome bc(1) complex. The conformations, of the inhibitor bound to the two enzymes are not the same. We focus on, the orientations of the stigmatellin side-chain relative to the chromone, head group, and on the interaction of the stigmatellin side-chain with, these membrane protein complexes. The different conformations of, stigmatellin found illustrate the structural variability of the Q sites, which are affected by the same inhibitor. The free rotation about the, chi(1) dihedral angle is an essential factor for allowing stigmatellin to, bind in both the reaction center and the cytochrome bc(1) pocket.
About this Structure
2IBZ is a Protein complex structure of sequences from Mus musculus and Saccharomyces cerevisiae with , , and as ligands. Active as Ubiquinol--cytochrome-c reductase, with EC number 1.10.2.2 Full crystallographic information is available from OCA.
Reference
A Comparison of Stigmatellin Conformations, Free and Bound to the Photosynthetic Reaction Center and the Cytochrome bc(1) Complex., Lancaster CR, Hunte C, Kelley J 3rd, Trumpower BL, Ditchfield R, J Mol Biol. 2007 Feb 11;. PMID:17337272
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