2igp
From Proteopedia
(New page: 200px<br /> <applet load="2igp" size="450" color="white" frame="true" align="right" spinBox="true" caption="2igp, resolution 1.80Å" /> '''Crystal Structure o...) |
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| - | [[Image:2igp. | + | [[Image:2igp.jpg|left|200px]]<br /><applet load="2igp" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2igp, resolution 1.80Å" /> | caption="2igp, resolution 1.80Å" /> | ||
'''Crystal Structure of Hec1 CH domain'''<br /> | '''Crystal Structure of Hec1 CH domain'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2IGP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with BME as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2IGP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=BME:'>BME</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGP OCA]. |
==Reference== | ==Reference== | ||
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[[Category: calponin homology (ch) domain]] | [[Category: calponin homology (ch) domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:36:12 2008'' |
Revision as of 15:36, 15 February 2008
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Crystal Structure of Hec1 CH domain
Overview
Kinetochores are multicomponent assemblies that connect chromosomal, centromeres to mitotic-spindle microtubules. The Ndc80 complex is an, essential core element of kinetochores, conserved from yeast to humans. It, is a rod-like assembly of four proteins- Ndc80p (HEC1 in humans), Nuf2p, Spc24p and Spc25p. We describe here the crystal structure of the most, conserved region of HEC1, which lies at one end of the rod and near the N, terminus of the polypeptide chain. It folds into a calponin-homology, domain, resembling the microtubule-binding domain of the, plus-end-associated protein EB1. We show that an Ndc80p-Nuf2p heterodimer, binds microtubules in vitro. The less conserved, N-terminal segment of, Ndc80p contributes to the interaction and may be a crucial regulatory, element. We propose that the Ndc80 complex forms a direct link between, kinetochore core components and spindle microtubules.
About this Structure
2IGP is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment., Wei RR, Al-Bassam J, Harrison SC, Nat Struct Mol Biol. 2007 Jan;14(1):54-9. Epub 2006 Dec 31. PMID:17195848
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