Phosphotransferase
From Proteopedia
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==3D structures of phosphotransferase== | ==3D structures of phosphotransferase== | ||
| - | ''Updated | + | ''Updated June 2012'' |
[[3our]] – PT IIA + pyruvate decarboxylase – ''Vibrio vulnificus''<BR /> | [[3our]] – PT IIA + pyruvate decarboxylase – ''Vibrio vulnificus''<BR /> | ||
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[[3ovc]] - EcAGPT IA<BR /> | [[3ovc]] - EcAGPT IA<BR /> | ||
| - | [[3r6z]] - EcAGPT IB<BR /> | + | [[3r6z]], [[3uzr]] - EcAGPT IB<BR /> |
[[3q2m]], [[3i1a]] – LpAGPT IA – ''Legionella pneumophila''<BR /> | [[3q2m]], [[3i1a]] – LpAGPT IA – ''Legionella pneumophila''<BR /> | ||
[[1nd4]] – KpAGPT IIA – ''Klebsiella pneumoniae''<BR /> | [[1nd4]] – KpAGPT IIA – ''Klebsiella pneumoniae''<BR /> | ||
[[1qhn]] – SvAGPT – ''Streptomyces venezuelae''<BR /> | [[1qhn]] – SvAGPT – ''Streptomyces venezuelae''<BR /> | ||
| - | [[3sgc]], [[3r7z]], [[3n4t]], [[3n4u]], [[3n4v]] - EncAGPT ID – ''Enterococcus casseliflavus''<BR /> | + | [[3sgc]], [[3r7z]], [[3n4t]], [[3n4u]], [[3n4v]] ,[[4dbx]], [[4de4]] - EncAGPT ID – ''Enterococcus casseliflavus''<BR /> |
[[1j7i]] - EfAGPT IIIA | [[1j7i]] - EfAGPT IIIA | ||
===Aminoglycoside phosphotransferase complex with nucleotide=== | ===Aminoglycoside phosphotransferase complex with nucleotide=== | ||
| - | [[3r70]] - EcAGPT IB + ADP<BR /> | + | [[3r70]], [[4dca]] - EcAGPT IB + ADP<BR /> |
[[3r78]] - EcAGPT IB + ATP<BR /> | [[3r78]] - EcAGPT IB + ATP<BR /> | ||
[[1qhx]] - SvAGPT + ATP<BR /> | [[1qhx]] - SvAGPT + ATP<BR /> | ||
[[3i0q]] - LpAGPT IA + AMP<BR /> | [[3i0q]] - LpAGPT IA + AMP<BR /> | ||
[[1j7l]] - EfAGPT IIIA + ADP <BR /> | [[1j7l]] - EfAGPT IIIA + ADP <BR /> | ||
| - | [[1j7u]] - EfAGPT IIIA + AMP-PNP | + | [[1j7u]] - EfAGPT IIIA + AMP-PNP <br /> |
| + | [[4ej7]] - AGPT IA + ATP – ''Acinetobacter baumanii''<br /> | ||
| + | [[4dt8]], [[4dt9]] - EncAGPT ID + nucleotide<br /> | ||
| + | [[4dta]], [[4dtb]] - EncAGPT ID (mutant) + nucleotide | ||
===Aminoglycoside phosphotransferase complex with antibiotic<br />=== | ===Aminoglycoside phosphotransferase complex with antibiotic<br />=== | ||
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[[1grq]], [[1grr]], [[1qhs]] - SvAGPT + antibiotic<br /> | [[1grq]], [[1grr]], [[1qhs]] - SvAGPT + antibiotic<br /> | ||
[[1qhy]] - SvAGPT + ATPγ + antibiotic<br /> | [[1qhy]] - SvAGPT + ATPγ + antibiotic<br /> | ||
| - | [[3sg8]], [[3sg9]] - EncAGPT ID + antibiotic<br /> | + | [[3sg8]], [[3sg9]], [[4dfb]], [[4dfu]] - EncAGPT ID + antibiotic<br /> |
[[3i0o]] - LpAGPT IA + ADP + antibiotic<br /> | [[3i0o]] - LpAGPT IA + ADP + antibiotic<br /> | ||
Revision as of 09:14, 21 June 2012
Template:STRUCTURE 3q2m
Phosphotransferase (PT) are enzymes which catalyze phosphorylation reactions. The acceptor group can be alcohol, carboxy, nitrogenous, phosphate or a pair ofd groups. Aminoglycoside PT (AGPT) inactivate aminoglycoside antibiotics by phosphorylation. The phosphoenolpyruvate-protein PT (PEP) catalyzes the phosphorylation of protein histidine residues. See Enzyme I of the Phosphoenolpyruvate:Sugar Phosphotransferase System and Enzyme I of the S. aureus PTS for some details and User:Karl Oberholser/Phosphoenolpyruvate:Sugar Phosphotransferase for a flash movie.
3D structures of phosphotransferase
Updated June 2012
3our – PT IIA + pyruvate decarboxylase – Vibrio vulnificus
2l5h, 2kx9 - EcPT I - Escherichia coli – NMR
2xdf - EcPT I+ phosphocarrier protein HPR – NMR
3oxp – PT II – Yersinia pestis
3ci6 – PT GAF domain – Acinetobacter
2ooc – PT histidine – Caulobacter crescentus
3ipj – PT IIABC – Clostridium difficile
2f9h - EfPT IIA – Enterococcus faecalis
1c02 - PT - yeast
Aminoglycoside phosphotransferase
3ovc - EcAGPT IA
3r6z, 3uzr - EcAGPT IB
3q2m, 3i1a – LpAGPT IA – Legionella pneumophila
1nd4 – KpAGPT IIA – Klebsiella pneumoniae
1qhn – SvAGPT – Streptomyces venezuelae
3sgc, 3r7z, 3n4t, 3n4u, 3n4v ,4dbx, 4de4 - EncAGPT ID – Enterococcus casseliflavus
1j7i - EfAGPT IIIA
Aminoglycoside phosphotransferase complex with nucleotide
3r70, 4dca - EcAGPT IB + ADP
3r78 - EcAGPT IB + ATP
1qhx - SvAGPT + ATP
3i0q - LpAGPT IA + AMP
1j7l - EfAGPT IIIA + ADP
1j7u - EfAGPT IIIA + AMP-PNP
4ej7 - AGPT IA + ATP – Acinetobacter baumanii
4dt8, 4dt9 - EncAGPT ID + nucleotide
4dta, 4dtb - EncAGPT ID (mutant) + nucleotide
Aminoglycoside phosphotransferase complex with antibiotic
3hav, 3ham - EfAGPT + ATP + antibiotic
3h8p, 3tm0 - EfAGPT + AMP-PNP + antibiotic
2b0q, 1l8t - EfAGPT IIIA + ADP + antibiotic
3r80, 3r81 - EcAGPT ID + antibiotic
1grq, 1grr, 1qhs - SvAGPT + antibiotic
1qhy - SvAGPT + ATPγ + antibiotic
3sg8, 3sg9, 4dfb, 4dfu - EncAGPT ID + antibiotic
3i0o - LpAGPT IA + ADP + antibiotic
Aminoglycoside phosphotransferase complex with inhibitor
2bkk, 3q2j - EfAGPT IIIA + inhibitor
Phosphoenolpyruvate-protein phosphotransferase
2xz7 – TtPEP PEP-binding domain + phosphoenolpyruvate – Thermoanaerobacter tengcongensis
2xz9 - TtPEP PEP-binding domain + pyruvate
3nbm – PEP lactose-specific IIBC – Streptococcus pneumoniae
2l2q - PEP cellbiose-specific IIB – Borrelia burgdorferi – NMR
3k1s - PEP cellbiose-specific IIA – Bacillus anthracis
2kyr – EcPEP fructose-specific IIB
2r4q - BsPEP fructose-specific IIABC – Bacillus subtilis
2r48 - BsPEP fructose-specific IIB
1vsq, 2jzh, 2jzn, 2jzo - EcPEP mannose-specific IIA - NMR
3bp3 - EcPEP glucose-specific IIB
1o53 - EcPEP glucose-specific IIA N terminal – NMR
1ggr - EcPEP glucose-specific IIA + phosphocarrier protein HPR – NMR
3bp8 - EcPEP glucose-specific IIB + NAGC-like transcriptional regulator
3eye - EcPEP acetylgalactosamine-specific IIB
2oq3, 1vrv - EcPEP mannitol-specific IIA
1vkr - EcPEP mannitol-specific IIABC – NMR
1j6t - EcPEP mannitol-specific IIABC + phosphocarrier protein HPR – NMR
2few - EcPEP mannitol-specific IIA (mutant)
1wcr - EcPEP diacetylchitobiose-specific IIA (mutant) – NMR
1h9c - EcPEP diacetylchitobiose-specific IIB – NMR
2hwg - EcPEP
3ipr – EfPEP gluconate-specific IIA
3bed - EfPEP mannose-specific IIA
1nrz - KpPEP sorbose-specific IIB
2hro – PEP – Staphylococcus carnosus
2wqd - PEP (mutant) – Staphylococcus aureus
3trc - PEP (mutant) – Coxiella burnetii
1f51, 1pey, 2ftk – BsPT sporulation initiation
1pux - BsPT sporulation initiation – NMR
2jvi, 2jvj, 2jvk - BsPT sporulation initiation (mutant) – NMR
3q15 - BsPT sporulation initiation + response regulator aspartate phosphatase
1fyn – PT SH3 domain + polyproline peptide - human
