2nn6
From Proteopedia
(New page: 200px<br /> <applet load="2nn6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2nn6, resolution 3.35Å" /> '''Structure of the hu...) |
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caption="2nn6, resolution 3.35Å" /> | caption="2nn6, resolution 3.35Å" /> | ||
'''Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40'''<br /> | '''Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2NN6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 2NN6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb86_1.html Exosomes]]. Full crystallographic information is available from [http:// | + | 2NN6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 2NN6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb86_1.html Exosomes]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NN6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: rna]] | [[Category: rna]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:39:18 2008'' |
Revision as of 15:39, 15 February 2008
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Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40
Overview
The RNA exosome is a multisubunit 3' to 5' exoribonuclease complex that, participates in degradation and processing of cellular RNA. To determine, the activities and structure of the eukaryotic exosome, we report the, reconstitution of 9-subunit exosomes from yeast and human and, reconstitution of 10- and 11-subunit exosomes from yeast. Comparative, biochemical analysis between purified subunits and reconstituted exosomes, using AU-rich, polyadenylated (poly[A]), generic, and structured RNA, substrates reveals processive phosphorolytic activities for human, Rrp41/Rrp45 and the 9-subunit human exosome, processive hydrolytic, activities for yeast Rrp44 and the yeast 10-subunit exosome, distributive, hydrolytic activities for Rrp6, and processive and distributive hydrolytic, activities for the yeast 11-subunit exosome. To elucidate the architecture, of a eukaryotic exosome, its conserved surfaces, and the structural basis, for RNA decay, we report the X-ray structure determination for the 286 kDa, nine-subunit human exosome at 3.35 A.
About this Structure
2NN6 is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 2NN6 with [Exosomes]. Full crystallographic information is available from OCA.
Reference
Reconstitution, activities, and structure of the eukaryotic RNA exosome., Liu Q, Greimann JC, Lima CD, Cell. 2006 Dec 15;127(6):1223-37. PMID:17174896
Page seeded by OCA on Fri Feb 15 17:39:18 2008
Categories: Exosomes | Homo sapiens | Protein complex | Lima, C.D. | Exoribonuclease | Exosome | Phosphorolytic | Pm/scl | Ribonuclease | Rna
