2grt
From Proteopedia
(New page: 200px<br /> <applet load="2grt" size="450" color="white" frame="true" align="right" spinBox="true" caption="2grt, resolution 2.70Å" /> '''HUMAN GLUTATHIONE R...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2GRT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FAD and GDS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.4.2 1.6.4.2]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GRT OCA]]. | + | 2GRT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FAD and GDS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_1.8.1.7 Transferred entry: 1.8.1.7]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.4.2 1.6.4.2]]. Structure known Active Site: S1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GRT OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Transferred entry: 1.8.1.7]] | ||
[[Category: Krauth-Siegel, R.L.]] | [[Category: Krauth-Siegel, R.L.]] | ||
[[Category: Pai, E.F.]] | [[Category: Pai, E.F.]] | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:26:22 2007'' |
Revision as of 11:21, 30 October 2007
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HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED GLUTATHIONE COMPLEX
Overview
Trypanosoma and Leishmania, pathogens responsible for diseases such as, African sleeping sickness, Chagas' heart disease, or Oriental sore, are, two of the very few genera that do not use the ubiquitous, glutathione/glutathione reductase system to keep a stable cellular redox, balance. Instead, they rely on trypanothione and trypanothione reductase, to protect them from oxidative stress. Trypanothione reductase (TR) and, the corresponding host enzyme, human red blood cell glutathione reductase, (GR), belong to the same flavoprotein family. Despite their closely, related three-dimensional structures and although their natural substrates, share the common structural glutathione core, the two enzymes are mutually, exclusive with respect to their disulfide substrates. This makes the, parasite ... [(full description)]
About this Structure
2GRT is a [Single protein] structure of sequence from [Homo sapiens] with FAD and GDS as [ligands]. Active as [Transferred entry: 1.8.1.7], with EC number [1.6.4.2]. Structure known Active Site: S1. Full crystallographic information is available from [OCA].
Reference
Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity., Stoll VS, Simpson SJ, Krauth-Siegel RL, Walsh CT, Pai EF, Biochemistry. 1997 May 27;36(21):6437-47. PMID:9174360
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