2seb
From Proteopedia
(New page: 200px<br /> <applet load="2seb" size="450" color="white" frame="true" align="right" spinBox="true" caption="2seb, resolution 2.5Å" /> '''X-RAY CRYSTAL STRUCT...) |
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| - | [[Image:2seb. | + | [[Image:2seb.jpg|left|200px]]<br /><applet load="2seb" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2seb, resolution 2.5Å" /> | caption="2seb, resolution 2.5Å" /> | ||
'''X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II'''<br /> | '''X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2SEB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2SEB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SEB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: complex (mhc class ii/superantigen)]] | [[Category: complex (mhc class ii/superantigen)]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:42:10 2008'' |
Revision as of 15:42, 15 February 2008
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X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II
Contents |
Overview
Genetic predisposition to rheumatoid arthritis (RA) is linked to the MHC, class II allele HLA-DR4. The charge of the amino acid at DRbeta71 in the, peptide-binding site appears to be critical in discriminating DR molecules, linked to increased disease susceptibility. We have determined the 2.5 A, x-ray structure of the DR4 molecule with the strongest linkage to RA, (DRB1*0401) complexed with a human collagen II peptide. Details of a, predicted salt bridge between lysine DRbeta71 and aspartic acid at the P4, peptide position suggest how it may participate in both antigen binding, and TCR activation. A model is proposed for the DR4 recognition of, collagen II (261-273), an antigen immunodominant in human-transgenic mouse, models of RA.
Disease
Known diseases associated with this structure: Achondrogenesis-hypochondrogenesis, type II OMIM:[120140], Epiphyseal dysplasia, multiple, with myopia and deafness OMIM:[120140], Kniest dysplasia OMIM:[120140], Osteoarthrosis OMIM:[120140], Platys OMIM:[120140], SED congenita OMIM:[120140], SMD OMIM:[120140], SMED Strudwick type OMIM:[120140], Spondyloperipheral dysplasia OMIM:[120140], Stickler syndrome, type I OMIM:[120140], Vitreoretinopathy with phalangeal epiphyseal dysplasia OMIM:[120140]
About this Structure
2SEB is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus with as ligand. Full crystallographic information is available from OCA.
Reference
X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II., Dessen A, Lawrence CM, Cupo S, Zaller DM, Wiley DC, Immunity. 1997 Oct;7(4):473-81. PMID:9354468
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