1uqu
From Proteopedia
(New page: 200px<br /> <applet load="1uqu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uqu, resolution 2.00Å" /> '''TREHALOSE-6-PHOSPHA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1UQU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with UPG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.15 2.4.1.15]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UQU OCA]]. | + | 1UQU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with UPG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Alpha,alpha-trehalose-phosphate_synthase_(UDP-forming) Alpha,alpha-trehalose-phosphate synthase (UDP-forming)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.15 2.4.1.15]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UQU OCA]]. |
==Reference== | ==Reference== | ||
The donor subsite of trehalose-6-phosphate synthase: binary complexes with UDP-glucose and UDP-2-deoxy-2-fluoro-glucose at 2 A resolution., Gibson RP, Tarling CA, Roberts S, Withers SG, Davies GJ, J Biol Chem. 2004 Jan 16;279(3):1950-5. Epub 2003 Oct 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14570926 14570926] | The donor subsite of trehalose-6-phosphate synthase: binary complexes with UDP-glucose and UDP-2-deoxy-2-fluoro-glucose at 2 A resolution., Gibson RP, Tarling CA, Roberts S, Withers SG, Davies GJ, J Biol Chem. 2004 Jan 16;279(3):1950-5. Epub 2003 Oct 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14570926 14570926] | ||
| + | [[Category: Alpha,alpha-trehalose-phosphate synthase (UDP-forming)]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:26:58 2007'' |
Revision as of 11:22, 30 October 2007
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TREHALOSE-6-PHOSPHATE FROM E. COLI BOUND WITH UDP-GLUCOSE.
Overview
Trehalose is an unusual non-reducing disaccharide that plays a variety of, biological roles, from food storage to cellular protection from, environmental stresses such as desiccation, pressure, heat-shock, extreme, cold, and oxygen radicals. It is also an integral component of the, cell-wall glycolipids of mycobacteria. The primary enzymatic route to, trehalose first involves the transfer of glucose from a UDP-glucose donor, to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate. This, reaction, in which the configurations of two glycosidic bonds are set, simultaneously, is catalyzed by the glycosyltransferase, trehalose-6-phosphate synthase (OtsA), which acts with retention of the, anomeric configuration of the UDP-sugar donor. The classification of, activated ... [(full description)]
About this Structure
1UQU is a [Single protein] structure of sequence from [Escherichia coli] with UPG as [ligand]. Active as [Alpha,alpha-trehalose-phosphate synthase (UDP-forming)], with EC number [2.4.1.15]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The donor subsite of trehalose-6-phosphate synthase: binary complexes with UDP-glucose and UDP-2-deoxy-2-fluoro-glucose at 2 A resolution., Gibson RP, Tarling CA, Roberts S, Withers SG, Davies GJ, J Biol Chem. 2004 Jan 16;279(3):1950-5. Epub 2003 Oct 21. PMID:14570926
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