Test 2558 2406

(Difference between revisions)

Revision as of 07:08, 27 June 2012

Revision as of 07:07, 27 June 2012 (edit) Alexander Berchansky (Talk \| contribs) ← Previous diff		Revision as of 07:08, 27 June 2012 (edit) (undo) Alexander Berchansky (Talk \| contribs) Next diff →
Line 1:		Line 1:
	<StructureSection load='2w9i' size='500' side='right' scene='Test_2558_2406/Cv/1' caption=''>		<StructureSection load='2w9i' size='500' side='right' scene='Test_2558_2406/Cv/1' caption=''>

-	<scene name='Test_2558_2406/Cv/2'>MB</scene> is a noncompetitive inhibitor of TcAChE, competing with reversible inhibitors directed at both ‘‘anionic’’ subsites, but a single site is involved in inhibition. The crystal structure reveals a single MB stacked against Trp279 in the PAS, oriented down the gorge toward the CAS ([[2w9i]]); it is plausible that irreversible inhibition is associated with photooxidation of this residue and others within the active-site gorge.	+	<scene name='Test_2558_2406/Cv/3'>MB</scene> is a noncompetitive inhibitor of TcAChE, competing with reversible inhibitors directed at both ‘‘anionic’’ subsites, but a single site is involved in inhibition. The crystal structure reveals a single MB stacked against Trp279 in the PAS, oriented down the gorge toward the CAS ([[2w9i]]); it is plausible that irreversible inhibition is associated with photooxidation of this residue and others within the active-site gorge.