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Test 2558 2406
From Proteopedia
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<StructureSection load='2w9i' size='500' side='right' scene='Test_2558_2406/Cv/1' caption=''> | <StructureSection load='2w9i' size='500' side='right' scene='Test_2558_2406/Cv/1' caption=''> | ||
| - | <scene name='Test_2558_2406/Cv/3'>MB</scene> is a noncompetitive inhibitor of TcAChE, competing with reversible inhibitors directed at both ‘‘anionic’’ subsites, but a single site is involved in inhibition. The crystal structure reveals a single MB stacked against Trp279 in the PAS, oriented down the gorge toward the CAS ([[2w9i]]); it is plausible that irreversible inhibition is associated with photooxidation of this residue and others within the active-site gorge. | + | <scene name='Test_2558_2406/Cv/3'>MB</scene> is a noncompetitive inhibitor of TcAChE, competing with reversible inhibitors directed at both ‘‘anionic’’ subsites, but a single site is involved in inhibition. The crystal structure reveals a single <scene name='Test_2558_2406/Cv/4'>MB stacked against Trp279 in the PAS</scene>, oriented down the gorge toward the CAS ([[2w9i]]); it is plausible that irreversible inhibition is associated with photooxidation of this residue and others within the active-site gorge. |
Revision as of 07:14, 27 June 2012
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