Test 2558 2406
From Proteopedia
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<StructureSection load='2w9i' size='500' side='right' scene='Test_2558_2406/Cv/1' caption=''> | <StructureSection load='2w9i' size='500' side='right' scene='Test_2558_2406/Cv/1' caption=''> | ||
| - | <scene name='Test_2558_2406/Cv/3'>MB</scene> is a noncompetitive inhibitor of TcAChE, competing with reversible inhibitors directed at both ‘‘anionic’’ subsites, but a single site is involved in inhibition. The crystal structure reveals a single <scene name='Test_2558_2406/Cv/4'>MB stacked against Trp279 in the PAS</scene>, oriented down the gorge toward the CAS ([[2w9i]]); it is plausible that irreversible inhibition is associated with photooxidation of this residue and others within the active-site gorge. Superposition of the PAS regions of the MB/TcAChE ([[2w9i]]) and thioflavin T/TcAChE ([[2j3q]]) complexes reveals <scene name='Test_2558_2406/Cv/ | + | <scene name='Test_2558_2406/Cv/3'>MB</scene> is a noncompetitive inhibitor of TcAChE, competing with reversible inhibitors directed at both ‘‘anionic’’ subsites, but a single site is involved in inhibition. The crystal structure reveals a single <scene name='Test_2558_2406/Cv/4'>MB stacked against Trp279 in the PAS</scene>, oriented down the gorge toward the CAS ([[2w9i]]); it is plausible that irreversible inhibition is associated with photooxidation of this residue and others within the active-site gorge. Superposition of the PAS regions of the MB/TcAChE ([[2w9i]]) and thioflavin T/TcAChE ([[2j3q]]) complexes reveals <scene name='Test_2558_2406/Cv/6'>similarity between positions of these ligands</scene>. |
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