4gal
From Proteopedia
(New page: 200px<br /> <applet load="4gal" size="450" color="white" frame="true" align="right" spinBox="true" caption="4gal, resolution 1.95Å" /> '''CRYSTAL STRUCTURE O...) |
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caption="4gal, resolution 1.95Å" /> | caption="4gal, resolution 1.95Å" /> | ||
'''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH LACTOSE'''<br /> | '''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH LACTOSE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 4GAL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 4GAL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: lectin]] | [[Category: lectin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:44:50 2008'' |
Revision as of 15:44, 15 February 2008
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH LACTOSE
Overview
Knowledge about carbohydrate recognition domains of galectins, formerly, known as S-type animal lectins, is important in understanding their, role(s) in cell-cell interactions. Here we report the crystal structure of, human galectin-7 (hGal-7), in free form and in the presence of galactose, galactosamine, lactose, and N-acetyl-lactosamine at high resolution. This, is the first structure of a galectin determined in both free and, carbohydrate-bound forms. The structure shows a fold similar to that of, the prototype galectins -1 and -2, but has greater similarity to a related, galectin molecule, Gal-10. Even though the carbohydrate-binding residues, are conserved, there are significant changes in this pocket due to, shortening of a loop structure. The monomeric hGal-7 molecule exists as a, dimer in the crystals, but adopts a packing arrangement considerably, different from that of Gal-1 and Gal-2, which has implications for, carbohydrate recognition.
About this Structure
4GAL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for the recognition of carbohydrates by human galectin-7., Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR, Biochemistry. 1998 Oct 6;37(40):13930-40. PMID:9760227
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