Hox protein

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[[Image:Hox-intro.jpg|thumb|left|200px|Figure 1: Crystal structure of Exd-Scr-DNA ternary complex; PDB ID# 2R5Z <ref name="joshi">Joshi R, Passner JM, Rohs R, Jain R, Sosinsky A, Crickmore MA, Jacob V, Aggarwal AK, Honig B, Mann RS. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell. 2007;131(3):530-43.</ref>.]]
[[Image:Hox-intro.jpg|thumb|left|200px|Figure 1: Crystal structure of Exd-Scr-DNA ternary complex; PDB ID# 2R5Z <ref name="joshi">Joshi R, Passner JM, Rohs R, Jain R, Sosinsky A, Crickmore MA, Jacob V, Aggarwal AK, Honig B, Mann RS. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell. 2007;131(3):530-43.</ref>.]]
[[Image:Cell.jpg|thumb|right|300px|Figure 2: Latent specificity of Hox proteins <ref name="slattery">Slattery M, Riley T, Liu P, Abe N, Gomez-Alcala P, Dror I, Zhou T, Rohs R, Honig B, Bussemaker HJ, Mann RS. Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins. Cell. 2011;147(6):1270-82.</ref>.]]
[[Image:Cell.jpg|thumb|right|300px|Figure 2: Latent specificity of Hox proteins <ref name="slattery">Slattery M, Riley T, Liu P, Abe N, Gomez-Alcala P, Dror I, Zhou T, Rohs R, Honig B, Bussemaker HJ, Mann RS. Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins. Cell. 2011;147(6):1270-82.</ref>.]]
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Hox proteins are transcription factors that play a key role in the embryonic development across species. In ''Drosophila'' eight Hox proteins are responsible for the development of different segments of the fly, for example its antennae, wings, or legs. Various Hox proteins execute these distinct functions through binding to closely related but different in vivo binding sites. This page discusses the mechanisms through which Hox proteins recognize their DNA binding sites with very high binding specificity.
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Hox proteins are transcription factors that play a key role in the embryonic development across species. In ''Drosophila'' eight Hox proteins are responsible for the development of different body segments of the fly, for example its antennae, wings, or legs. Various Hox proteins execute these distinct functions through binding to closely related but different in vivo binding sites. This page discusses the mechanisms through which Hox proteins recognize their DNA binding sites with very high binding specificity.
</StructureSection><Structure load='2r5z' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
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===References===
===References===
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Hox Proteins Specifically Recognize the Sequence-Dependent Shape of the Minor Groove

Biological Role of Hox Proteins

Figure 1: Crystal structure of Exd-Scr-DNA ternary complex; PDB ID# 2R5Z .
Figure 1: Crystal structure of Exd-Scr-DNA ternary complex; PDB ID# 2R5Z [1].
Figure 2: Latent specificity of Hox proteins .
Figure 2: Latent specificity of Hox proteins [2].

Hox proteins are transcription factors that play a key role in the embryonic development across species. In Drosophila eight Hox proteins are responsible for the development of different body segments of the fly, for example its antennae, wings, or legs. Various Hox proteins execute these distinct functions through binding to closely related but different in vivo binding sites. This page discusses the mechanisms through which Hox proteins recognize their DNA binding sites with very high binding specificity.

</StructureSection>

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Drag the structure with the mouse to rotate

Caption .
Caption [1].
Image:Slattery-etal-Figure6.jpg
Caption [2].
Caption .
Caption [1].

References

  1. ↑ 1.0 1.1 1.2 Joshi R, Passner JM, Rohs R, Jain R, Sosinsky A, Crickmore MA, Jacob V, Aggarwal AK, Honig B, Mann RS. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell. 2007;131(3):530-43.
  2. ↑ 2.0 2.1 Slattery M, Riley T, Liu P, Abe N, Gomez-Alcala P, Dror I, Zhou T, Rohs R, Honig B, Bussemaker HJ, Mann RS. Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins. Cell. 2011;147(6):1270-82.
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