Thioredoxin
From Proteopedia
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== 3D Structures of Thioredoxin == | == 3D Structures of Thioredoxin == | ||
| - | ''Updated | + | ''Updated July 2012'' |
=== Trx === | === Trx === | ||
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[[2vim]] – Trx – ''Fasciola hepatica''<br /> | [[2vim]] – Trx – ''Fasciola hepatica''<br /> | ||
[[2yzu]], [[2cvk]], [[1v98]] – TtTrx – ''Thermus thermophilus''<br /> | [[2yzu]], [[2cvk]], [[1v98]] – TtTrx – ''Thermus thermophilus''<br /> | ||
| + | [[2lst]] – TtTrx - NMR<br /> | ||
[[2e0q]] – Trx (mutant) – ''Sulfolobus tokodaii''<br /> | [[2e0q]] – Trx (mutant) – ''Sulfolobus tokodaii''<br /> | ||
[[2o7k]] – SaTrx<br /> | [[2o7k]] – SaTrx<br /> | ||
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[[1xw9]], [[1xwa]], [[1xwb]], [[1xwc]] – Trx – ''Drosophila melanogaster''<br /> | [[1xw9]], [[1xwa]], [[1xwb]], [[1xwc]] – Trx – ''Drosophila melanogaster''<br /> | ||
[[1rqm]], [[1nsw]], [[1nw2]] – Trx (mutant) – ''Alicyclobacillus acidocaldarius'' – NMR<br /> | [[1rqm]], [[1nsw]], [[1nw2]] – Trx (mutant) – ''Alicyclobacillus acidocaldarius'' – NMR<br /> | ||
| - | [[1syr]] – | + | [[1syr]] – PfTrx – ''Plasmodium falciparum''<br /> |
[[1r26]] – Trx – ''Trypanosoma brucei brucei''<br /> | [[1r26]] – Trx – ''Trypanosoma brucei brucei''<br /> | ||
[[1gl8]] – Trx – spinach- NMR<br /> | [[1gl8]] – Trx – spinach- NMR<br /> | ||
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[[2xbi]] – SmTrx – ''Schistosoma mansoni''<br /> | [[2xbi]] – SmTrx – ''Schistosoma mansoni''<br /> | ||
[[2xbq]], [[2xc2]] – SmTrx (mutant) | [[2xbq]], [[2xc2]] – SmTrx (mutant) | ||
| - | |||
=== Trx-1 === | === Trx-1 === | ||
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[[1t7p]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+ddAMP+ddGTP<br /> | [[1t7p]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+ddAMP+ddGTP<br /> | ||
[[2bto]] – Trx-1+tubulin btuba – ''Prosthecobacter dejongeii''<br /> | [[2bto]] – Trx-1+tubulin btuba – ''Prosthecobacter dejongeii''<br /> | ||
| - | [[1oaz]] – Trx-1+immunoglobulin E – rat | + | [[1oaz]] – Trx-1+immunoglobulin E – rat<br /> |
| - | + | [[3tco]] - SsTrx-1 fragment – ''Sulfolobus solfataricus'' | |
=== Trx-2 === | === Trx-2 === | ||
[[1w4v]], [[1w89]], [[1uvz]] – hTrx-2 <br /> | [[1w4v]], [[1w89]], [[1uvz]] – hTrx-2 <br /> | ||
| - | [[3hhv]] – | + | [[3hhv]] – SsTrx-2 fragment <br /> |
[[2fa4]] – yTrx-2<br /> | [[2fa4]] – yTrx-2<br /> | ||
[[2hsy]] – yTrx-2 - NMR<br /> | [[2hsy]] – yTrx-2 - NMR<br /> | ||
[[3pin]] - yTrx-2+peptide methionine sulfoxide reductase<br /> | [[3pin]] - yTrx-2+peptide methionine sulfoxide reductase<br /> | ||
[[2ppt]] – Trx-2 – ''Rhodobacter capsulatus''<br /> | [[2ppt]] – Trx-2 – ''Rhodobacter capsulatus''<br /> | ||
| - | [[1thx]] – Trx-2 – Anabaena | + | [[1thx]] – Trx-2 – Anabaena<br /> |
| - | + | [[3ul3]] – PfTrx-2 | |
=== Trx-3 === | === Trx-3 === | ||
[[2oe0]], [[2oe1]], [[2oe3]] – yTrx-3 | [[2oe0]], [[2oe1]], [[2oe3]] – yTrx-3 | ||
| - | |||
=== Trx C === | === Trx C === | ||
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[[1f9m]] – sTrx F – spinach<br /> | [[1f9m]] – sTrx F – spinach<br /> | ||
[[1faa]] - sTrx F (mutant) | [[1faa]] - sTrx F (mutant) | ||
| - | |||
=== Trx H === | === Trx H === | ||
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[[1ti3]] - pTrx H - NMR<br /> | [[1ti3]] - pTrx H - NMR<br /> | ||
[[2vlt]], [[2vlu]], [[2vlv]], [[2vm1]], [[2vm2]] - bTrx H – barley<br /> | [[2vlt]], [[2vlu]], [[2vlv]], [[2vm1]], [[2vm2]] - bTrx H – barley<br /> | ||
| - | [[2iwt]] - bTrx H+ | + | [[2iwt]] - bTrx H+α-amylase subtilisin inhibitor<br /> |
[[1wmj]] – Trx H – ''Oryza sativa'' – NMR<br /> | [[1wmj]] – Trx H – ''Oryza sativa'' – NMR<br /> | ||
[[1xfl]] – Trx H – ''Arabidopsis thaliana'' - NMR<br /> | [[1xfl]] – Trx H – ''Arabidopsis thaliana'' - NMR<br /> | ||
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[[1ep8]] - CrTrx H (mutant)<br /> | [[1ep8]] - CrTrx H (mutant)<br /> | ||
[[1tof]] - CrTrx H - NMR | [[1tof]] - CrTrx H - NMR | ||
| - | |||
=== Trx M === | === Trx M === | ||
Revision as of 07:57, 3 July 2012
Thioredoxin (Trx) is an enzyme which facilitates the reduction of proteins by cysteine thiol-disulfide exchange. They contain a CXXC motif. Trx-1 is a mammalian cellular protein. Trx-2 is mitochondria-specific. In higher plants, Trx are divided to 6 groups based on their sequence. Trx M, X and Y are found in prokaryotes while F, H and O are found in eukaryotes. The images at the left and at the right correspond to one representative Trx, i.e. the crystal structure of human Thioredoxin (1ert).
Contents |
3D Structures of Thioredoxin
Updated July 2012
Trx
3e3e, 2hsh, 1aiu, 1erv, 1erw, 3m9j, 3m9k – hTrx (mutant) – human
3kd0 - hTrx (mutant)+CdCl2
1cqg, 1cqh - hTrx (mutant)+Ref-1 peptide – NMR
1mdi, 1mdj, 1mdk - hTrx + Target peptide of NFKB – NMR
2hxk, 2ifq, 2iiy – hTrx S-nitroso
1auc, 1ert, 1eru, 1trs, 1tru, 1trv, 1trw, 3trx, 4trx - hTrx
3hxs – BfTrx fragment – Bacteroides fragilis
3hyp - BfrxI fragment (mutant)
3hz4 – Trx – Methanosarcina mazei
2k9f - Trx fragment+DsbD N-terminal – Neisseria meningitides – NMR
3die – SaTrx (mutant) – Staphylococcus aureus
2voc - BsTrx (mutant) – Bacillus subtilis
2gzy, 2gzz – BsTrx – NMR
2ipa – BsTrx (mutant)+ArcS (mutant) - NMR
2h6x, 2trx, 1srx – EcTrx
1xoa, 1xob – EcTrx - NMR
1m7t – hTrx/EcTrx chimera - NMR
3dxb – hTrx+Puf60 C-terminal
3emx – Trx – Aeropyrum pernix
2vim – Trx – Fasciola hepatica
2yzu, 2cvk, 1v98 – TtTrx – Thermus thermophilus
2lst – TtTrx - NMR
2e0q – Trx (mutant) – Sulfolobus tokodaii
2o7k – SaTrx
2o85, 2o87, 2o89 – SaTrx (mutant)
2i4a – Trx – Acetobacter aceti
2j23 – Trx – Malassezia sympodialis
2f51 – Trx – Trichomonas vaginalis
1t00 – Trx – Streptomyces coelicolor
1xw9, 1xwa, 1xwb, 1xwc – Trx – Drosophila melanogaster
1rqm, 1nsw, 1nw2 – Trx (mutant) – Alicyclobacillus acidocaldarius – NMR
1syr – PfTrx – Plasmodium falciparum
1r26 – Trx – Trypanosoma brucei brucei
1gl8 – Trx – spinach- NMR
1fo5 – Trx – Methanocaldococcus janaschii – NMR
1quw – Trx – Bacillus acidocaldarius – NMR
2l5l – Trx – Bacteroides vulgatus – NMR
2tir - EcTrx (mutant) – Escherichia coli
2xbi – SmTrx – Schistosoma mansoni
2xbq, 2xc2 – SmTrx (mutant)
Trx-1
3f3q, 2i9h – yTrx-1 – yeast
3f3r – yTrx-1 (mutant)
3dyr, 2h6y, 2h6z, 2h70, 2h71, 2h72, 2h73, 2h74, 2h75, 2h76, 2fch, 2fd3, 1keb, 2eio, 2eiq, 2eir, 1zcp, 1zzy, 1txx, 1tho – EcTrx-1 (mutant)
1f6m – EcTrx-1+Trx reductase+AADP+
2ajq – EpTrx-1 (mutant)+DNA primer+DNA template+DNA polymerase – Enterobacteria phage T7
1zyq – EpTrx-1 (mutant)+DNA primer+DNA template+DNA polymerase+ATP
1x9m, 1x9s, 1x9w – EpTrx-1+DNA primer+DNA template+DNA polymerase+N-2-acetylaminofluorene-adducted DNA
1t8e – EpTrx-1 +DNA primer+DNA template+DNA polymerase+dCTP
1tk0 – EpTrx-1+DNA primer+DNA template+DNA polymerase+ddCTP+8-oxo-guanosine
1tk5 - EpTrx-1+DNA primer+DNA template+DNA polymerase+8-oxo-guanosine
1tk8 - EpTrx-1+DNA primer+DNA template+DNA polymerase+dAMP+8-oxo-guanosine
1tkd - EpTrx-1+DNA primer+DNA template+DNA polymerase+dCMP+8-oxo-guanosine
1skr - EpTrx-1+DNA primer+DNA template+DNA polymerase+ddATP
1sks, 1skw, 1sl0, 1sl1, 1sl2 - EpTrx-1+DNA primer+DNA template+DNA polymerase+thymine
1t7p - EpTrx-1+DNA primer+DNA template+DNA polymerase+ddAMP+ddGTP
2bto – Trx-1+tubulin btuba – Prosthecobacter dejongeii
1oaz – Trx-1+immunoglobulin E – rat
3tco - SsTrx-1 fragment – Sulfolobus solfataricus
Trx-2
1w4v, 1w89, 1uvz – hTrx-2
3hhv – SsTrx-2 fragment
2fa4 – yTrx-2
2hsy – yTrx-2 - NMR
3pin - yTrx-2+peptide methionine sulfoxide reductase
2ppt – Trx-2 – Rhodobacter capsulatus
1thx – Trx-2 – Anabaena
3ul3 – PfTrx-2
Trx-3
Trx C
2i1u – MtTrx C – Mycobacterium tuberculosis
2l4q, 2l59 – MtTrx C - NMR
3nof – MtTrx (mutant)
3o6t – MtTrx (mutant)+quinol
Trx F
2pu9 – SsTrx F+ferredoxin thioredoxin reductase – Synechocystis
2pvo - SsTrx F+ferredoxin thioredoxin reductase+ferredoxin 1
1f9m – sTrx F – spinach
1faa - sTrx F (mutant)
Trx H
3d21 – pTrx H – poplar
3d22 - pTrx H (mutant)
1ti3 - pTrx H - NMR
2vlt, 2vlu, 2vlv, 2vm1, 2vm2 - bTrx H – barley
2iwt - bTrx H+α-amylase subtilisin inhibitor
1wmj – Trx H – Oryza sativa – NMR
1xfl – Trx H – Arabidopsis thaliana - NMR
1ep7 – CrTrx H – Chlamydomonas reinhardtii
1ep8 - CrTrx H (mutant)
1tof - CrTrx H - NMR
Trx M
2puk - SsTrx M+ferredoxin thioredoxin reductase
1fb0, 1fb6 - sTrx M
1dby – CrTrx M – NMR
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Laura Maria Batista Leal, Joel L. Sussman
