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1kmb

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(New page: 200px<br /> <applet load="1kmb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kmb, resolution 2.1&Aring;" /> '''SELECTIN-LIKE MUTANT...)
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==About this Structure==
==About this Structure==
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1KMB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with CA and CL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KMB OCA]].
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1KMB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with CA and CL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: 11, 12, 13, 21, 22, 23, 31, 32 and 33. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KMB OCA]].
==Reference==
==Reference==
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[[Category: lectin]]
[[Category: lectin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:38:07 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:27:26 2007''

Revision as of 11:22, 30 October 2007

Image:1kmb.gif

1kmb, resolution 2.1Å

Drag the structure with the mouse to rotate

SELECTIN-LIKE MUTANT OF MANNOSE-BINDING PROTEIN A

Overview

Rat serum mannose-binding protein in which residues 211-213 have been, changed to the Lys-Lys-Lys sequence found in E-selectin binds HL-60 cells, and the oligosaccharide 3'-NeuAc-Le(x). To understand how this mutant, designated K3, mimics the carbohydrate-binding properties of E-selectin, structures of K3 alone and in complexes with 3'-NeuAc-Le(x), 3'-sulfo-Le(x) and 4'-sulfo-Le(x) have been determined at 1.95-2.1 A, resolution by X-ray crystallography. The region of K3 that interacts with, bound oligosaccharides superimposes closely with the corresponding region, of unliganded E-selectin. In each of the oligosaccharide-protein, complexes, the 2- and 3-OH of Fuc coordinate Ca2+ and form a network of, cooperative hydrogen bonds with amino acid side chains that also, coordinate the Ca2+. ... [(full description)]

About this Structure

1KMB is a [Single protein] structure of sequence from [Rattus norvegicus] with CA and CL as [ligands]. Structure known Active Sites: 11, 12, 13, 21, 22, 23, 31, 32 and 33. Full crystallographic information is available from [OCA].

Reference

Structure of a selectin-like mutant of mannose-binding protein complexed with sialylated and sulfated Lewis(x) oligosaccharides., Ng KK, Weis WI, Biochemistry. 1997 Feb 4;36(5):979-88. PMID:9033386

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