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| - | <applet load="1eve" size="450" color="white" frame="true" align="right" spinBox="true" script="1eve/E2020_in_ache/6" caption="PDB: 1eve (Can't see the molecule? Download Java at www.java.com)" />
| + | Eran Hodis |
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| - | <big>Welcome to Proteopedia,</big>
| + | eran.hodis at weizmann.ac.il |
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| - | The collaborative, 3D encyclopedia of proteins and other molecules.
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| - | ===Green links change the 3D image!===
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| - | <big>''Here's an excerpt from one of our pages:''</big>
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| - | The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/7'>unique orientation</scene> along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/3'>W84</scene>) of the active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/2'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <scene name='1eve/E20_interactionshown/3'>indirectly via solvent molecules</scene>.
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| - | ===See more!===
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| - | Here are three of our favorite pages. Visit them to get a feeling for Proteopedia:
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| - | * [[Hemoglobin]]
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| - | * [[1eve | Acetylcholinesterase with the anti-Alzheimer's drug Aricept bound]]
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| - | * [[1v04 | Serum Paraoxonase-1 created by directed evolution]].
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| - | ===How can I find my protein/molecule?===
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| - | Search Proteopedia using the search box in the toolbar to the left.
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| - | ===Want to contribute?===
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| - | We encourage you to '''edit pages freely''' (you need a user account to edit at the moment, so ask us for one).
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| - | '''To request a user account''', email '''eran.hodis''' ''at'' '''weizmann.ac.il'''
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| - | These resources may help you familiarize yourself with the editing process. Trust us, the editing process is very simple: All text is edited the same way that Wikipedia is edited, so it must be easy! And all scenes are created using our user-friendly ''Scene authoring tools''. Of course it helps to familiarize yourself with the site and how to go about editing, so check out these resources:
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| - | *A video capture of making a Proteopedia page in 4 minutes [http://www.proteopedia.org/Proteopedia.html here].
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| - | *A rough and temporary tutorial available [http://www.proteopedia.org/Proteopedia.html here].
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| - | *The [[Help:Editing | editing help page]].
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| - | *The help page for the [[Scene authoring tools]].
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| - | ===Proteopedia Mission Statement===
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| - | To collect and disseminate structural biological and biological knowledge about proteins, RNA, DNA, and their assemblies and interacting small molecules in a manner that is relevant and accessible to scientists of all the biological and chemical fields.
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| - | ===Goals for Proteopedia===
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| - | * To serve as a forum for scientists to share, retrieve and discuss information related to proteins, macromolecules, and small molecules and chemicals of interest.
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| - | * To continue to develop the concept of tying text to three-dimensional, interactive images.
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| - | * To maintain low barriers for contribution.
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