4ehz

(Difference between revisions)

Revision as of 07:38, 4 July 2012

4ehz is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Zak M, Mendonca R, Balazs M, Barrett K, Bergeron P, Blair WS, Chang C, Deshmukh G, Devoss J, Dragovich PS, Eigenbrot C, Ghilardi N, Gibbons P, Gradl S, Hamman C, Hanan EJ, Harstad E, Hewitt PR, Hurley CA, Jin T, Johnson A, Johnson T, Kenny JR, Koehler MF, Bir Kohli P, Kulagowski JJ, Labadie S, Liao J, Liimatta M, Lin Z, Lupardus PJ, Maxey RJ, Murray JM, Pulk R, Rodriguez M, Savage S, Shia S, Steffek M, Ubhayakar S, Ultsch M, van Abbema A, Ward SI, Xiao L, Xiao Y. Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2. J Med Chem. 2012 Jun 28. PMID:22698084 doi:10.1021/jm300628c

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-'''Unreleased structure'''
+[[Image:4ehz.jpg|left|200px]]
-The entry 4ehz is ON HOLD  until Paper Publication
+{{STRUCTURE_4ehz|  PDB=4ehz  |  SCENE=  }}
-Authors: Lupardus, P.J., Steffek, M.
+===The Jak1 kinase domain in complex with inhibitor===
-Description: The Jak1 kinase domain in complex with inhibitor
+{{ABSTRACT_PUBMED_22698084}}
+==About this Structure==
+[[4ehz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHZ OCA].
+==Reference==
+<ref group="xtra">PMID:022698084</ref><references group="xtra"/>
+[[Category: Homo sapiens]]
+[[Category: Non-specific protein-tyrosine kinase]]
+[[Category: Lupardus, P J.]]
+[[Category: Steffek, M.]]
+[[Category: Kinase]]
+[[Category: Transferase-inhibitor complex]]