4f08

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-	'''Unreleased structure'''	+	[[Image:4f08.jpg|left|200px]]
-	The entry 4f08 is ON HOLD until Paper Publication	+	{{STRUCTURE_4f08| PDB=4f08 | SCENE= }}
-	Authors: Murray, J.M.	+	===Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2===
-	Description: Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2	+	{{ABSTRACT_PUBMED_22698084}}
		+
		+	==About this Structure==
		+	[[4f08]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F08 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022698084</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Non-specific protein-tyrosine kinase]]
		+	[[Category: Murray, J M.]]
		+	[[Category: Jak2]]
		+	[[Category: Kinase domain]]
		+	[[Category: Transferase-transferase inhibitor complex]]

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Revision as of 07:39, 4 July 2012

Template:STRUCTURE 4f08

Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

Template:ABSTRACT PUBMED 22698084

About this Structure

4f08 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Zak M, Mendonca R, Balazs M, Barrett K, Bergeron P, Blair WS, Chang C, Deshmukh G, Devoss J, Dragovich PS, Eigenbrot C, Ghilardi N, Gibbons P, Gradl S, Hamman C, Hanan EJ, Harstad E, Hewitt PR, Hurley CA, Jin T, Johnson A, Johnson T, Kenny JR, Koehler MF, Bir Kohli P, Kulagowski JJ, Labadie S, Liao J, Liimatta M, Lin Z, Lupardus PJ, Maxey RJ, Murray JM, Pulk R, Rodriguez M, Savage S, Shia S, Steffek M, Ubhayakar S, Ultsch M, van Abbema A, Ward SI, Xiao L, Xiao Y. Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2. J Med Chem. 2012 Jun 28. PMID:22698084 doi:10.1021/jm300628c