Villin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the Human Supervillin Headpiece, [[2k6n]]]]
[[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the Human Supervillin Headpiece, [[2k6n]]]]
{{STRUCTURE_2k6n| right| PDB=2k6n | SCENE=Villin/Cv/1 |CAPTION=Human Supervillin Headpiece, [[2k6n]] }}
{{STRUCTURE_2k6n| right| PDB=2k6n | SCENE=Villin/Cv/1 |CAPTION=Human Supervillin Headpiece, [[2k6n]] }}
 +
 +
 +
 +
 +
 +

Revision as of 06:28, 5 July 2012

Image:2k6n.png
Crystal Strcture of the Human Supervillin Headpiece, 2k6n

Template:STRUCTURE 2k6n















Villin (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin[1]. Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons. The images on the left and right correspond to one representative villin structure, i.e. the human supervillin headpiece (2k6n).


Contents

3D Structures of Villin

Update December 2011




Supervillin

2k6m, 2k6n – hSVIL headpiece– human – NMR

Villin

3fg7 – hVIL gelsolin domains 4-6
1unc – hVIL headpiece
3iur - hVIL headpiece H2H3 helices+prolyl endopeptidase – Aeromonas punctata
2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
1yu5, 1qqv - cVIL headpiece
3myc, 3mye, 3nkj, 3mya - cVIL headpiece (mutant)
1vii, 2vik, 2vil - cVIL headpiece - NMR
2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic

Advillin

1und – hAVIL headpiece

References

  1. ↑ Friederich E, Vancompernolle K, Louvard D, Vandekerckhove J. Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 1999 Sep 17;274(38):26751-60. PMID:10480879
Retrieved from "http://52.214.119.220/wiki/index.php/Villin"
Personal tools