Eric Martz's Favorites
From Proteopedia
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==Eric Martz's Favorites== | ==Eric Martz's Favorites== | ||
| - | * 2006 - Tamiflu bound to avian influenza neuraminidase N1, [[2hu4]] has tamiflu bound, while [[2hty]] lacks this ligand. Tamiflu was designed for N2/N9, not N1. Its antiviral activity via N1 is fortunate but surprising. Comparison of these two structures shows that tamiflu pulls N1 loop 147-152 into close contact, a case of "induced fit". Another surprise was a cavity near tamiflu that could serve as a target for designing better anti-avian influenza drugs. | + | * 2006 - '''Tamiflu bound to avian influenza neuraminidase N1''', [[2hu4]] has tamiflu bound, while [[2hty]] lacks this ligand. Tamiflu was designed for N2/N9, not N1. Its antiviral activity via N1 is fortunate but surprising. Comparison of these two structures shows that tamiflu pulls N1 loop 147-152 into close contact, a case of "induced fit". Another surprise was a cavity near tamiflu that could serve as a target for designing better anti-avian influenza drugs. |
| - | ** | + | ** [http://www.umass.edu/molvis/martz/lectures/labmolgen07/n1tami.htm More background]. |
| - | ** | + | ** [http://www.umass.edu/molvis/martz/lectures/labmolgen07/index.htm Lesson plan on this topic]. |
| + | ** [http://www.umass.edu/molvis/martz/lectures/labmolgen07/index.htm#examples Morphs of the induced fit]. | ||
| + | ** [http://www.bioinformatics.org/jmol-tutorials/jtat/jtatdemo/ch_view2/chapter.htm Cavity near tamiflu] is shown nicely in '''View 2''' of this chapter in a tutorial about developing tutorials using Jmol. | ||
Revision as of 05:15, 21 February 2008
Eric Martz's Favorites
- 2006 - Tamiflu bound to avian influenza neuraminidase N1, 2hu4 has tamiflu bound, while 2hty lacks this ligand. Tamiflu was designed for N2/N9, not N1. Its antiviral activity via N1 is fortunate but surprising. Comparison of these two structures shows that tamiflu pulls N1 loop 147-152 into close contact, a case of "induced fit". Another surprise was a cavity near tamiflu that could serve as a target for designing better anti-avian influenza drugs.
- More background.
- Lesson plan on this topic.
- Morphs of the induced fit.
- Cavity near tamiflu is shown nicely in View 2 of this chapter in a tutorial about developing tutorials using Jmol.
