Estrogen-related receptor
From Proteopedia
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| + | {{STRUCTURE_2pgu| PDB=2pgu | SIZE=400| SCENE= |right|CAPTION=Human estrogen-related receptor γ complex with 4-hydroxytamoxifen, [[2pgu]] }} | ||
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| - | + | '''Estrogen-related receptor''' (ERR) binds to estrogen response elements on DNA and modulates transcription. ERR plays a role in energy homeostasis and cancer. There are 3 classes of ERR : ERRα, ERRβ and ERRγ. | |
==3D structures of estrogen-related receptor== | ==3D structures of estrogen-related receptor== | ||
Revision as of 10:26, 8 July 2012
Estrogen-related receptor (ERR) binds to estrogen response elements on DNA and modulates transcription. ERR plays a role in energy homeostasis and cancer. There are 3 classes of ERR : ERRα, ERRβ and ERRγ.
Contents |
3D structures of estrogen-related receptor
ERRα
1xb7, [[3d24 – hERR ligand-binding domain + peroxisome proliferator activated receptor coactivator 1 peptide – human
2pjl - hERR ligand-binding domain (mutant) + inverse agonist
3k6p - hERR ligand-binding domain + ligand
ERRβ
1lo1 – hERR DNA-binding domain + DNA
ERRγ
2gp7, 2zbs - hERR ligand-binding domain
1kv6, 1tfc – hERR ligand-binding domain + steroid receptor coactivator 1 2nd NR-Box
2gpo, 2gpp - hERR ligand-binding domain + nuclear receptor-interacting protein 1 peptide
2ewp - hERR ligand-binding domain + tamoxifen analog
2gpu, 2p7z - hERR ligand-binding domain + 4-hydroxytamoxifen
2e2r, 2p7g - hERR ligand-binding domain + bisphenol A
2zkc - hERR ligand-binding domain + bisphenol Z
2zas - hERR ligand-binding domain + bisphenol A derivative
2p7a - hERR ligand-binding domain + methyl phenol
2gpv - hERR ligand-binding domain + nuclear receptor corepressor 2 peptide + 4-hydroxytamoxifen
1s9p - mERR ligand-binding domain + diethylstilbesterol – mouse
1vjb - mERR ligand-binding domain + 4-hydroxytamoxifen
