Variable lymphocyte receptor

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{{STRUCTURE_2o6q| PDB=2o6q | SIZE=400| SCENE= |right| CAPTION=Inshore hagfish variable lymphocyte receptor leucin-rich repeat, [[2o6q]] }}
{{STRUCTURE_2o6q| PDB=2o6q | SIZE=400| SCENE= |right| CAPTION=Inshore hagfish variable lymphocyte receptor leucin-rich repeat, [[2o6q]] }}
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Variable lymphocyte receptors (VLRs) are [[leucine-rich repeat]] (LRR) family proteins that mediate adaptive immune responses in the jawless vertebrates, lampreys and hagfish. <ref>PMID: 17192264</ref>
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[[Image:3g3a biol unitsurf.png|370px|right|thumb| [[Lamprey Variable Lymphocyte Receptor]] in complex with a protein antigen ([[3g3a]])]]
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See [[Lamprey Variable Lymphocyte Receptor]] for details.
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{{STRUCTURE_3g3a| PDB=3g3a | SCENE=Variable_Lymphocyte_Receptors/3g3a_biological_unit/3 |CAPTION= Variable lymphocyte receptor of lamprey bound to a protein antigen ([[3g3a]]), resolution 2.20&Aring;}}
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Articles in Proteopedia concerning Variable lymphocyte receptors include:
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*[[Lamprey Variable Lymphocyte Receptor]]
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==References==
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<references/>
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==See Also==
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*[[leucine-rich repeat|Leucine-rich Repeat Proteins]]
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*[[Antibody]]
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*[[Forkhead box protein]]
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==Additional Literature==
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<ref group="xtra">PMID: 21293377</ref><ref group="xtra">PMID: 20660361</ref><ref group="xtra">PMID: 20482318</ref><ref group="xtra">PMID: 19543291</ref><ref group="xtra">PMID: 20660361</ref> <ref group="xtra">PMID: 18238899 </ref><ref group="xtra">PMID: 18818359 </ref><references group="xtra"/>See [[Lamprey Variable Lymphocyte Receptor]] for details.
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Revision as of 10:55, 10 July 2012

Template:STRUCTURE 2o6q Variable lymphocyte receptors (VLRs) are leucine-rich repeat (LRR) family proteins that mediate adaptive immune responses in the jawless vertebrates, lampreys and hagfish. [1]

Lamprey Variable Lymphocyte Receptor in complex with a protein antigen (3g3a)
Lamprey Variable Lymphocyte Receptor in complex with a protein antigen (3g3a)

Template:STRUCTURE 3g3a


Articles in Proteopedia concerning Variable lymphocyte receptors include:


References

  1. ↑ Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO. Structural diversity of the hagfish variable lymphocyte receptors. J Biol Chem. 2007 Mar 2;282(9):6726-32. Epub 2006 Dec 27. PMID:17192264 doi:10.1074/jbc.M608471200

See Also

Additional Literature

  • Bajoghli B, Guo P, Aghaallaei N, Hirano M, Strohmeier C, McCurley N, Bockman DE, Schorpp M, Cooper MD, Boehm T. A thymus candidate in lampreys. Nature. 2011 Feb 3;470(7332):90-4. PMID:21293377 doi:10.1038/nature09655
  • Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
  • Mariuzza RA, Velikovsky CA, Deng L, Xu G, Pancer Z. Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates. Biol Chem. 2010 Jul;391(7):753-60. PMID:20482318 doi:10.1515/BC.2010.091
  • Velikovsky CA, Deng L, Tasumi S, Iyer LM, Kerzic MC, Aravind L, Pancer Z, Mariuzza RA. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol. 2009 Jul;16(7):725-30. Epub 2009 Jun 21. PMID:19543291 doi:10.1038/nsmb.1619
  • Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
  • Herrin BR, Alder MN, Roux KH, Sina C, Ehrhardt GR, Boydston JA, Turnbough CL Jr, Cooper MD. Structure and specificity of lamprey monoclonal antibodies. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2040-5. Epub 2008 Jan 31. PMID:18238899 doi:10.1073/pnas.0711619105
  • Han BW, Herrin BR, Cooper MD, Wilson IA. Antigen recognition by variable lymphocyte receptors. Science. 2008 Sep 26;321(5897):1834-7. PMID:18818359 doi:321/5897/1834
See Lamprey Variable Lymphocyte Receptor for details.

Contents

3D structures of variable lymphocyte receptor

Updated December 2011

3m19, 3g39, 2r9u - mlVLR ectodomain – marine lamprey
3m18, 3g3a – mlVLR ectodomain + lysozyme
3g3b - mlVLR ectodomain (mutant) + lysozyme
3e6j - mlVLR ectodomain + trisaccharide
2o6q, 2o6r, 2o6s – IhVLR leucine-rich repeat – inshore hagfish
2z62, 2z63, 2z66 – IhVLR/hTLR4
2z80, 2z81, 2z82, 3a78, 3a7c – IhVLR/hTLR2
2z65 – IhVLR/hTLR4 + lymphocyte antigen 96
2z7x – IhVLR/hTLR1 + IhVLR/hTLR2 + tri-acylated lipopeptide
3a79 - IhVLR/hTLR2 + IhVLR/hTLR6 + tri-acylated lipopeptide

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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