This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1gve
From Proteopedia
(New page: 200px<br /> <applet load="1gve" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gve, resolution 1.38Å" /> '''AFLATOXIN ALDEHYDE ...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GVE is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with NAP, CIT and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GVE OCA]]. | + | 1GVE is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with NAP, CIT and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GVE OCA]]. |
==Reference== | ==Reference== | ||
| Line 26: | Line 26: | ||
[[Category: succinic semialdehyde oxidoreductase]] | [[Category: succinic semialdehyde oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:28:33 2007'' |
Revision as of 11:23, 30 October 2007
|
AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER
Overview
The structure of the rat liver aflatoxin dialdehyde reductase (AKR7A1) has, been solved to 1.38-A resolution. Although it shares a similar, alpha/beta-barrel structure with other members of the aldo-keto reductase, superfamily, AKR7A1 is the first dimeric member to be crystallized. The, crystal structure also reveals details of the ternary complex as one, subunit of the dimer contains NADP(+) and the inhibitor citrate. Although, the underlying catalytic mechanism appears similar to other aldo-keto, reductases, the substrate-binding pocket contains several charged amino, acids (Arg-231 and Arg-327) that distinguish it from previously, characterized aldo-keto reductases with respect to size and charge. These, differences account for the substrate specificity for 4-carbon, acid-aldehydes ... [(full description)]
About this Structure
1GVE is a [Protein complex] structure of sequences from [Rattus norvegicus] with NAP, CIT and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily., Kozma E, Brown E, Ellis EM, Lapthorn AJ, J Biol Chem. 2002 May 3;277(18):16285-93. Epub 2002 Feb 11. PMID:11839745
Page seeded by OCA on Tue Oct 30 13:28:33 2007
