1gvz
From Proteopedia
(New page: 200px<br /> <applet load="1gvz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gvz, resolution 1.42Å" /> '''PROSTATE SPECIFIC A...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GVZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]] with ACT and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GVZ OCA]]. | + | 1GVZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]] with ACT and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GVZ OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: prostate specific antigen]] | [[Category: prostate specific antigen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:28:36 2007'' |
Revision as of 11:23, 30 October 2007
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PROSTATE SPECIFIC ANTIGEN (PSA) FROM STALLION SEMINAL PLASMA
Overview
Prostate-specific kallikrein, a member of the gene family of serine, proteases, was initially discovered in semen and is the most useful serum, marker for prostate cancer diagnosis and prognosis. We report the crystal, structure at 1.42A resolution of horse prostate kallikrein (HPK). This is, the first structure of a serine protease purified from seminal plasma. HPK, shares extensive sequence homology with human prostate-specific antigen, (PSA), including a predicted chymotrypsin-like specificity, as suggested, by the presence of a serine residue at position S1 of the specificity, pocket. In contrast to other kallikreins, HPK shows a structurally, distinct specificity pocket. Its entrance is blocked by the kallikrein, loop, suggesting a possible protective or substrate-selective role for, ... [(full description)]
About this Structure
1GVZ is a [Single protein] structure of sequence from [Equus caballus] with ACT and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: a homologue of human PSA., Carvalho AL, Sanz L, Barettino D, Romero A, Calvete JJ, Romao MJ, J Mol Biol. 2002 Sep 13;322(2):325-37. PMID:12217694
Page seeded by OCA on Tue Oct 30 13:28:36 2007
