103d
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The centromere of human chromosomes contains multiple repeats of the DNA | + | The centromere of human chromosomes contains multiple repeats of the DNA sequence d(TGGAA)n. This sequence has the interesting property of pairing with itself to form stable duplexes. We have determined the solution structure of the unusual DNA duplex 5'-TGGAATGGAA:TGGAATGGAA-3' at atomic resolution. The duplex contains unpaired staggered guanosine residues, which co-stack by intercalation between sheared G.A and A.G base-pairs to form an interesting new structural motif, the GA-bracketed G-stack. The TGGAA repeat unit contains six "steps", four of which are not Watson-Crick base-pairs. |
==About this Structure== | ==About this Structure== | ||
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The unusual structure of the human centromere (GGA)2 motif. Unpaired guanosine residues stacked between sheared G.A pairs., Chou SH, Zhu L, Reid BR, J Mol Biol. 1994 Dec 2;244(3):259-68. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7966337 7966337] | The unusual structure of the human centromere (GGA)2 motif. Unpaired guanosine residues stacked between sheared G.A pairs., Chou SH, Zhu L, Reid BR, J Mol Biol. 1994 Dec 2;244(3):259-68. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7966337 7966337] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Chou, S | + | [[Category: Chou, S H.]] |
| - | [[Category: Reid, B | + | [[Category: Reid, B R.]] |
[[Category: Zhu, L.]] | [[Category: Zhu, L.]] | ||
[[Category: dna]] | [[Category: dna]] | ||
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[[Category: nmr]] | [[Category: nmr]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:37:18 2008'' |
Revision as of 09:37, 21 February 2008
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THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS
Overview
The centromere of human chromosomes contains multiple repeats of the DNA sequence d(TGGAA)n. This sequence has the interesting property of pairing with itself to form stable duplexes. We have determined the solution structure of the unusual DNA duplex 5'-TGGAATGGAA:TGGAATGGAA-3' at atomic resolution. The duplex contains unpaired staggered guanosine residues, which co-stack by intercalation between sheared G.A and A.G base-pairs to form an interesting new structural motif, the GA-bracketed G-stack. The TGGAA repeat unit contains six "steps", four of which are not Watson-Crick base-pairs.
About this Structure
103D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
The unusual structure of the human centromere (GGA)2 motif. Unpaired guanosine residues stacked between sheared G.A pairs., Chou SH, Zhu L, Reid BR, J Mol Biol. 1994 Dec 2;244(3):259-68. PMID:7966337
Page seeded by OCA on Thu Feb 21 11:37:18 2008
