16vp

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(New page: 200px<br /><applet load="16vp" size="450" color="white" frame="true" align="right" spinBox="true" caption="16vp, resolution 2.1&Aring;" /> '''CONSERVED CORE OF THE...)
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[[Image:16vp.gif|left|200px]]<br /><applet load="16vp" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:16vp.gif|left|200px]]<br /><applet load="16vp" size="350" color="white" frame="true" align="right" spinBox="true"
caption="16vp, resolution 2.1&Aring;" />
caption="16vp, resolution 2.1&Aring;" />
'''CONSERVED CORE OF THE HERPES SIMPLEX VIRUS TRANSCRIPTIONAL REGULATORY PROTEIN VP16'''<br />
'''CONSERVED CORE OF THE HERPES SIMPLEX VIRUS TRANSCRIPTIONAL REGULATORY PROTEIN VP16'''<br />
==Overview==
==Overview==
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On infection, the herpes simplex virus (HSV) virion protein VP16 (Vmw65;, alphaTIF) forms a transcriptional regulatory complex-the VP16-induced, complex-with two cellular proteins, HCF and Oct-1, on VP16-responsive, cis-regulatory elements in HSV immediate-early promoters called TAATGARAT., Comparison of different HSV VP16 sequences reveals a conserved core region, that is sufficient for VP16-induced complex formation. The crystal, structure of the VP16 core has been determined at 2.1 A resolution. The, results reveal a novel, seat-like protein structure. Together with the, activity of mutant VP16 proteins, the structure of free VP16 suggests that, it contains (1) a disordered carboxy-terminal region that associates with, HCF, Oct-1, and DNA in the VP16-induced complex, and (2) a structured, region involved in virion assembly and possessing a novel DNA-binding, surface that differentiates among TAATGARAT VP16-response elements.
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On infection, the herpes simplex virus (HSV) virion protein VP16 (Vmw65; alphaTIF) forms a transcriptional regulatory complex-the VP16-induced complex-with two cellular proteins, HCF and Oct-1, on VP16-responsive cis-regulatory elements in HSV immediate-early promoters called TAATGARAT. Comparison of different HSV VP16 sequences reveals a conserved core region that is sufficient for VP16-induced complex formation. The crystal structure of the VP16 core has been determined at 2.1 A resolution. The results reveal a novel, seat-like protein structure. Together with the activity of mutant VP16 proteins, the structure of free VP16 suggests that it contains (1) a disordered carboxy-terminal region that associates with HCF, Oct-1, and DNA in the VP16-induced complex, and (2) a structured region involved in virion assembly and possessing a novel DNA-binding surface that differentiates among TAATGARAT VP16-response elements.
==About this Structure==
==About this Structure==
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16VP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_6 Human herpesvirus 6] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=16VP OCA].
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16VP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_6 Human herpesvirus 6] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=16VP OCA].
==Reference==
==Reference==
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[[Category: Gong, W.]]
[[Category: Gong, W.]]
[[Category: Herr, W.]]
[[Category: Herr, W.]]
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[[Category: Huang, C.C.]]
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[[Category: Huang, C C.]]
[[Category: Liu, Y.]]
[[Category: Liu, Y.]]
[[Category: SO4]]
[[Category: SO4]]
[[Category: transcriptional regulatory protein]]
[[Category: transcriptional regulatory protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:29:21 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:38:45 2008''

Revision as of 09:38, 21 February 2008

Image:16vp.gif

16vp, resolution 2.1Å

Drag the structure with the mouse to rotate

CONSERVED CORE OF THE HERPES SIMPLEX VIRUS TRANSCRIPTIONAL REGULATORY PROTEIN VP16

Overview

On infection, the herpes simplex virus (HSV) virion protein VP16 (Vmw65; alphaTIF) forms a transcriptional regulatory complex-the VP16-induced complex-with two cellular proteins, HCF and Oct-1, on VP16-responsive cis-regulatory elements in HSV immediate-early promoters called TAATGARAT. Comparison of different HSV VP16 sequences reveals a conserved core region that is sufficient for VP16-induced complex formation. The crystal structure of the VP16 core has been determined at 2.1 A resolution. The results reveal a novel, seat-like protein structure. Together with the activity of mutant VP16 proteins, the structure of free VP16 suggests that it contains (1) a disordered carboxy-terminal region that associates with HCF, Oct-1, and DNA in the VP16-induced complex, and (2) a structured region involved in virion assembly and possessing a novel DNA-binding surface that differentiates among TAATGARAT VP16-response elements.

About this Structure

16VP is a Single protein structure of sequence from Human herpesvirus 6 with as ligand. Full crystallographic information is available from OCA.

Reference

Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16., Liu Y, Gong W, Huang CC, Herr W, Cheng X, Genes Dev. 1999 Jul 1;13(13):1692-703. PMID:10398682

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