3qlh

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'''Unreleased structure'''
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[[Image:3qlh.png|left|200px]]
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The entry 3qlh is ON HOLD until Paper Publication
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{{STRUCTURE_3qlh| PDB=3qlh | SCENE= }}
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Authors: Himmel, D.M., Wojak, K., Bauman, J.D., Arnold, E.
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===HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket===
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Description: HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpilvirine) at the NNRTI Binding Pocket
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{{ABSTRACT_PUBMED_21568335}}
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==About this Structure==
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[[3qlh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dulacia_guianensis Dulacia guianensis] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLH OCA].
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==Reference==
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<ref group="xtra">PMID:021568335</ref><ref group="xtra">PMID:020004166</ref><ref group="xtra">PMID:018676450</ref><references group="xtra"/>
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[[Category: Dulacia guianensis]]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Arnold, E.]]
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[[Category: Bauman, J D.]]
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[[Category: Himmel, D M.]]
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[[Category: Wojtak, K.]]
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[[Category: Divalent cation chelator]]
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[[Category: Hydrolase-inhibitor complex]]
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[[Category: Non-nucleoside rt inhibitor]]
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[[Category: Rnase h inhibitor]]
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[[Category: Structure-based drug design]]
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[[Category: Transferase]]
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[[Category: Tropolone derivative]]

Revision as of 04:43, 18 July 2012

Image:3qlh.png

Template:STRUCTURE 3qlh

HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket

Template:ABSTRACT PUBMED 21568335

About this Structure

3qlh is a 2 chain structure with sequence from Dulacia guianensis and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

  • Chung S, Himmel DM, Jiang JK, Wojtak K, Bauman JD, Rausch JW, Wilson JA, Beutler JA, Thomas CJ, Arnold E, Le Grice SF. Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J Med Chem. 2011 Jul 14;54(13):4462-73. Epub 2011 Jun 2. PMID:21568335 doi:10.1021/jm2000757
  • Himmel DM, Maegley KA, Pauly TA, Bauman JD, Das K, Dharia C, Clark AD Jr, Ryan K, Hickey MJ, Love RA, Hughes SH, Bergqvist S, Arnold E. Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Structure. 2009 Dec 9;17(12):1625-35. PMID:20004166 doi:10.1016/j.str.2009.09.016
  • Bauman JD, Das K, Ho WC, Baweja M, Himmel DM, Clark AD Jr, Oren DA, Boyer PL, Hughes SH, Shatkin AJ, Arnold E. Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Nucleic Acids Res. 2008 Sep;36(15):5083-92. Epub 2008 Aug 1. PMID:18676450 doi:10.1093/nar/gkn464

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