1a0t
From Proteopedia
(New page: 200px<br /><applet load="1a0t" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a0t, resolution 2.4Å" /> '''SUCROSE-SPECIFIC PORI...) |
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| - | [[Image:1a0t.gif|left|200px]]<br /><applet load="1a0t" size=" | + | [[Image:1a0t.gif|left|200px]]<br /><applet load="1a0t" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1a0t, resolution 2.4Å" /> | caption="1a0t, resolution 2.4Å" /> | ||
'''SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES'''<br /> | '''SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The X-ray structure of a sucrose-specific porin (ScrY) from Salmonella | + | The X-ray structure of a sucrose-specific porin (ScrY) from Salmonella typhimurium has been determined by multiple isomorphous replacement at 2.4 A resolution both in its uncomplexed form and with bound sucrose. ScrY is a noncrystallographic trimer of identical subunits, each with 413 structurally well-defined amino acids. A monomer is built up of 18 anti-parallel beta-strands surrounding a hydrophilic pore, with a topology closely similar to that of maltoporin. Two non-overlapping sucrose-binding sites were identified in difference Fourier maps. The higher permeability for sucrose of ScrY as compared to maltoporin is mainly accounted for by differences in their pore-lining residues. |
==About this Structure== | ==About this Structure== | ||
| - | 1A0T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium] with SUC and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1A0T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium] with <scene name='pdbligand=SUC:'>SUC</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0T OCA]. |
==Reference== | ==Reference== | ||
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[[Category: porin]] | [[Category: porin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:39:36 2008'' |
Revision as of 09:39, 21 February 2008
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SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES
Overview
The X-ray structure of a sucrose-specific porin (ScrY) from Salmonella typhimurium has been determined by multiple isomorphous replacement at 2.4 A resolution both in its uncomplexed form and with bound sucrose. ScrY is a noncrystallographic trimer of identical subunits, each with 413 structurally well-defined amino acids. A monomer is built up of 18 anti-parallel beta-strands surrounding a hydrophilic pore, with a topology closely similar to that of maltoporin. Two non-overlapping sucrose-binding sites were identified in difference Fourier maps. The higher permeability for sucrose of ScrY as compared to maltoporin is mainly accounted for by differences in their pore-lining residues.
About this Structure
1A0T is a Single protein structure of sequence from Salmonella typhimurium with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the sucrose-specific porin ScrY from Salmonella typhimurium and its complex with sucrose., Forst D, Welte W, Wacker T, Diederichs K, Nat Struct Biol. 1998 Jan;5(1):37-46. PMID:9437428
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