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4dii

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'''Unreleased structure'''
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[[Image:4dii.jpg|left|200px]]
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The entry 4dii is ON HOLD until Paper Publication
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{{STRUCTURE_4dii| PDB=4dii | SCENE= }}
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Authors: Russo Krauss, I., Merlino, A., Mazzarella, L., Sica, F.
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===X-ray structure of the complex between human alpha thrombin and thrombin binding aptamer in the presence of potassium ions===
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Description: X-ray structure of the complex between human alpha thrombin and thrombin binding aptamer in the presence of potassium ions
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{{ABSTRACT_PUBMED_22669903}}
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==About this Structure==
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[[4dii]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DII OCA].
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==Reference==
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<ref group="xtra">PMID:022669903</ref><ref group="xtra">PMID:021715374</ref><ref group="xtra">PMID:008102368</ref><ref group="xtra">PMID:015299700</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Thrombin]]
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[[Category: Krauss, I Russo.]]
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[[Category: Mazzarella, L.]]
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[[Category: Merlino, A.]]
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[[Category: Sica, F.]]
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[[Category: Aptamer]]
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[[Category: Blood]]
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[[Category: Blood coagulation]]
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[[Category: Dna aptamer]]
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[[Category: G-quadruplex]]
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[[Category: Hydrolase-hydrolase inhibitor-dna complex]]
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[[Category: Protein-dna complex]]
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[[Category: Serine protease]]
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[[Category: Serine protease fold]]

Revision as of 05:22, 18 July 2012

Image:4dii.jpg

Template:STRUCTURE 4dii

X-ray structure of the complex between human alpha thrombin and thrombin binding aptamer in the presence of potassium ions

Template:ABSTRACT PUBMED 22669903

About this Structure

4dii is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Russo Krauss I, Merlino A, Randazzo A, Novellino E, Mazzarella L, Sica F. High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity. Nucleic Acids Res. 2012 Jun 4. PMID:22669903 doi:10.1093/nar/gks512
  • Russo Krauss I, Merlino A, Giancola C, Randazzo A, Mazzarella L, Sica F. Thrombin-aptamer recognition: a revealed ambiguity. Nucleic Acids Res. 2011 Sep 1;39(17):7858-67. Epub 2011 Jun 28. PMID:21715374 doi:10.1093/nar/gkr522
  • Padmanabhan K, Padmanabhan KP, Ferrara JD, Sadler JE, Tulinsky A. The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer. J Biol Chem. 1993 Aug 25;268(24):17651-4. PMID:8102368
  • Padmanabhan K, Tulinsky A. An ambiguous structure of a DNA 15-mer thrombin complex. Acta Crystallogr D Biol Crystallogr. 1996 Mar 1;52(Pt 2):272-82. PMID:15299700 doi:10.1107/S0907444995013977

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