3um5

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-	'''Unreleased structure'''	+	[[Image:3um5.jpg|left|200px]]
-	The entry 3um5 is ON HOLD until Paper Publication	+	{{STRUCTURE_3um5| PDB=3um5 | SCENE= }}
-	Authors: Vanichtanankul, J., Kamchonwongpaisan, S., Chitnumsub, P., Yuthavong, Y.	+	===Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP===
-	Description: Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP	+	{{ABSTRACT_PUBMED_22526319}}
		+
		+	==About this Structure==
		+	[[3um5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UM5 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022526319</ref><references group="xtra"/>
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: Chitnumsub, P.]]
		+	[[Category: Kamchonwongpaisan, S.]]
		+	[[Category: Vanichtanankul, J.]]
		+	[[Category: Yuthavong, Y.]]
		+	[[Category: Antifolate]]
		+	[[Category: Dump]]
		+	[[Category: Malarial dhfr-t]]
		+	[[Category: Napdh]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Pyrimethamine]]
		+	[[Category: Transferase-inhibitor complex]]

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Revision as of 05:24, 18 July 2012

Template:STRUCTURE 3um5

Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP

Template:ABSTRACT PUBMED 22526319

About this Structure

3um5 is a 2 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

• Vanichtanankul J, Taweechai S, Uttamapinant C, Chitnumsub P, Vilaivan T, Yuthavong Y, Kamchonwongpaisan S. Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil. Antimicrob Agents Chemother. 2012 Jul;56(7):3928-35. Epub 2012 Apr 23. PMID:22526319 doi:10.1128/AAC.00301-12