1a58
From Proteopedia
(New page: 200px<br /><applet load="1a58" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a58, resolution 1.95Å" /> '''CYCLOPHILIN FROM BRU...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1a58.gif|left|200px]]<br /><applet load="1a58" size=" | + | [[Image:1a58.gif|left|200px]]<br /><applet load="1a58" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1a58, resolution 1.95Å" /> | caption="1a58, resolution 1.95Å" /> | ||
'''CYCLOPHILIN FROM BRUGIA MALAYI'''<br /> | '''CYCLOPHILIN FROM BRUGIA MALAYI'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A structure of residues 1-177 of the cyclophilin domain of a large | + | A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A. |
==About this Structure== | ==About this Structure== | ||
| - | 1A58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full crystallographic information is available from [http:// | + | 1A58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A58 OCA]. |
==Reference== | ==Reference== | ||
| Line 15: | Line 15: | ||
[[Category: Husi, H.]] | [[Category: Husi, H.]] | ||
[[Category: Kontopidis, G.]] | [[Category: Kontopidis, G.]] | ||
| - | [[Category: Page, A | + | [[Category: Page, A P.]] |
[[Category: Taylor, P.]] | [[Category: Taylor, P.]] | ||
| - | [[Category: Walkinshaw, M | + | [[Category: Walkinshaw, M D.]] |
[[Category: isomerase]] | [[Category: isomerase]] | ||
[[Category: ppiase]] | [[Category: ppiase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:40:59 2008'' |
Revision as of 09:40, 21 February 2008
|
CYCLOPHILIN FROM BRUGIA MALAYI
Overview
A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.
About this Structure
1A58 is a Single protein structure of sequence from Brugia malayi. Full crystallographic information is available from OCA.
Reference
The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi., Taylor P, Page AP, Kontopidis G, Husi H, Walkinshaw MD, FEBS Lett. 1998 Mar 27;425(2):361-6. PMID:9559680
Page seeded by OCA on Thu Feb 21 11:40:59 2008
