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4dtk

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{{STRUCTURE_4dtk| PDB=4dtk | SCENE= }}
{{STRUCTURE_4dtk| PDB=4dtk | SCENE= }}

Revision as of 06:21, 25 July 2012

Image:4dtk.png

Template:STRUCTURE 4dtk

Novel and selective pan-PIM kinase inhibitor

Template:ABSTRACT PUBMED 22727640

About this Structure

4dtk is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Dakin LA, Block MH, Chen H, Code E, Dowling JE, Feng X, Ferguson AD, Green I, Hird AW, Howard T, Keeton EK, Lamb ML, Lyne PD, Pollard H, Read J, Wu AJ, Zhang T, Zheng X. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4599-604. Epub 2012 Jun 6. PMID:22727640 doi:10.1016/j.bmcl.2012.05.098

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OCA

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