This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1w0y
From Proteopedia
(New page: 200px<br /> <applet load="1w0y" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w0y, resolution 2.50Å" /> '''TF7A_3771 COMPLEX''...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1W0Y is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FUC, BGC, CA, CAC and 771 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W0Y OCA]]. | + | 1W0Y is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FUC, BGC, CA, CAC and 771 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W0Y OCA]]. |
==Reference== | ==Reference== | ||
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15664864 15664864] | Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15664864 15664864] | ||
| + | [[Category: Coagulation factor VIIa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| Line 40: | Line 41: | ||
[[Category: vitamin k]] | [[Category: vitamin k]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:32:13 2007'' |
Revision as of 11:27, 30 October 2007
|
TF7A_3771 COMPLEX
Overview
Proof of concept experiments have shown that tissue factor/factor VIIa, inhibitors have antithrombotic activity without enhancing bleeding, propensity. Starting from lead compounds generated by a biased, combinatorial approach, phenylglycine amide tissue factor/factor VIIa, inhibitors with low nanomolar affinity and good selectivity against other, serine proteases of the coagulation cascade were designed, using the, guidance of X-ray structural analysis and molecular modelling.
About this Structure
1W0Y is a [Protein complex] structure of sequences from [Homo sapiens] with FUC, BGC, CA, CAC and 771 as [ligands]. Active as [Coagulation factor VIIa], with EC number [3.4.21.21]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864
Page seeded by OCA on Tue Oct 30 13:32:13 2007
Categories: Coagulation factor VIIa | Homo sapiens | Protein complex | Ackermann, J. | Arcy, A.D. | Banner, D.W. | Groebke-Zbinden, K. | Ji, Y.H. | Kirchhofer, D. | Tschopp, T.B. | Wallbaum, S. | Weber, L. | 771 | BGC | CA | CAC | FUC | Blood coagulation | Calcium-binding | Co-factor | Coagulation | Enzyme complex | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Plasma | Serine protease | Vitamin k
