1afv
From Proteopedia
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==Overview== | ==Overview== | ||
| - | X-ray diffraction analysis of a human immunodeficiency virus (HIV-1) | + | X-ray diffraction analysis of a human immunodeficiency virus (HIV-1) capsid (CA) protein shows that each monomer within the dimer consists of seven alpha-helices, five of which are arranged in a coiled coil-like structure. Sequence assignments were made for two of the helices, and tentative connectivity of the remainder of the protein was confirmed by the recent solution structure of a monomeric N-terminal fragment. The C-terminal third of the protein is mostly disordered in the crystal. The longest helices in the coiled coil-like structure are separated by a long, highly antigenic peptide that includes the binding site of an antibody fragment complexed with CA in the crystal. The site of binding of the Fab, the position of the antigenic loop and the site of cleavage between the matrix protein and CA establish the side of the dimer that would be on the exterior of the retroviral core. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Carter, C.]] | [[Category: Carter, C.]] | ||
| - | [[Category: Ehrlich, L | + | [[Category: Ehrlich, L S.]] |
| - | [[Category: Gitti, R | + | [[Category: Gitti, R K.]] |
| - | [[Category: Gorbalenya, A | + | [[Category: Gorbalenya, A E.]] |
[[Category: Keller, W.]] | [[Category: Keller, W.]] | ||
| - | [[Category: Kovari, L | + | [[Category: Kovari, L C.]] |
| - | [[Category: Lee, B | + | [[Category: Lee, B M.]] |
[[Category: Mcclure, J.]] | [[Category: Mcclure, J.]] | ||
[[Category: Momany, C.]] | [[Category: Momany, C.]] | ||
| - | [[Category: Prongay, A | + | [[Category: Prongay, A J.]] |
| - | [[Category: Rossmann, M | + | [[Category: Rossmann, M G.]] |
| - | [[Category: Summers, M | + | [[Category: Summers, M F.]] |
[[Category: Tong, L.]] | [[Category: Tong, L.]] | ||
[[Category: PB]] | [[Category: PB]] | ||
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[[Category: p24]] | [[Category: p24]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:44:07 2008'' |
Revision as of 09:44, 21 February 2008
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HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3
Overview
X-ray diffraction analysis of a human immunodeficiency virus (HIV-1) capsid (CA) protein shows that each monomer within the dimer consists of seven alpha-helices, five of which are arranged in a coiled coil-like structure. Sequence assignments were made for two of the helices, and tentative connectivity of the remainder of the protein was confirmed by the recent solution structure of a monomeric N-terminal fragment. The C-terminal third of the protein is mostly disordered in the crystal. The longest helices in the coiled coil-like structure are separated by a long, highly antigenic peptide that includes the binding site of an antibody fragment complexed with CA in the crystal. The site of binding of the Fab, the position of the antigenic loop and the site of cleavage between the matrix protein and CA establish the side of the dimer that would be on the exterior of the retroviral core.
About this Structure
1AFV is a Protein complex structure of sequences from Human immunodeficiency virus 1 and Mus musculus with as ligand. Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
Crystal structure of dimeric HIV-1 capsid protein., Momany C, Kovari LC, Prongay AJ, Keller W, Gitti RK, Lee BM, Gorbalenya AE, Tong L, McClure J, Ehrlich LS, Summers MF, Carter C, Rossmann MG, Nat Struct Biol. 1996 Sep;3(9):763-70. PMID:8784350
Page seeded by OCA on Thu Feb 21 11:44:07 2008
Categories: Human immunodeficiency virus 1 | Mus musculus | Protein complex | Carter, C. | Ehrlich, L S. | Gitti, R K. | Gorbalenya, A E. | Keller, W. | Kovari, L C. | Lee, B M. | Mcclure, J. | Momany, C. | Prongay, A J. | Rossmann, M G. | Summers, M F. | Tong, L. | PB | Capsid protein | Complex (viral capsid/immunoglobulin) | Hiv | P24
