1w0p
From Proteopedia
(New page: 200px<br /> <applet load="1w0p" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w0p, resolution 1.6Å" /> '''VIBRIO CHOLERAE SIAL...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W0P is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]] with SIA, CA, TRS and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W0P OCA]]. | + | 1W0P is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]] with SIA, CA, TRS and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W0P OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: vibrio cholerae]] | [[Category: vibrio cholerae]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:32:33 2007'' |
Revision as of 11:27, 30 October 2007
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VIBRIO CHOLERAE SIALIDASE WITH ALPHA-2,6-SIALYLLACTOSE
Overview
Vibrio cholerae neuraminidase (VCNA) plays a significant role in the, pathogenesis of cholera by removing sialic acid from higher order, gangliosides to unmask GM1, the receptor for cholera toxin. We previously, showed that the structure of VCNA is composed of a central beta-propeller, catalytic domain flanked by two lectin-like domains; however the nature of, the carbohydrates recognized by these lectin domains has remained unknown., We present here structures of the enzyme in complex with two substrates, alpha-2,3-sialyllactose and alpha-2,6-sialyllactose. Both substrate, complexes reveal the alpha-anomer of N-acetylneuraminic acid (Neu5Ac), bound to the N-terminal lectin domain, thereby revealing the role of this, domain. The large number of interactions suggest a relatively high ... [(full description)]
About this Structure
1W0P is a [Single protein] structure of sequence from [Vibrio cholerae] with SIA, CA, TRS and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Sialic acid recognition by Vibrio cholerae neuraminidase., Moustafa I, Connaris H, Taylor M, Zaitsev V, Wilson JC, Kiefel MJ, von Itzstein M, Taylor G, J Biol Chem. 2004 Sep 24;279(39):40819-26. Epub 2004 Jun 28. PMID:15226294
Page seeded by OCA on Tue Oct 30 13:32:33 2007
Categories: Single protein | Vibrio cholerae | Connaris, H. | Kiefel, M.J. | Moustafa, I. | Taylor, G. | Taylor, M. | Von-Itzstein, M. | Wilson, J.C. | Zaitsev, V. | CA | GOL | SIA | TRS | Lectin | Neuraminidase | Sialidase
