1ah1
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The structure of human CTLA-4 reveals that residues Met 99, Tyr 100 and | + | The structure of human CTLA-4 reveals that residues Met 99, Tyr 100 and Tyr 104 of the M99YPPPY104 motif are adjacent to a patch of charged surface residues on the A'GFCC' face of the protein. Mutation of these residues, which are conserved in the CTLA-4/CD28 family, significantly reduces binding to CD80 and/or CD86, implicating this patch as a ligand binding site. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bajorath, J.]] | [[Category: Bajorath, J.]] | ||
| - | [[Category: Constantine, K | + | [[Category: Constantine, K L.]] |
[[Category: Fenderson, W.]] | [[Category: Fenderson, W.]] | ||
| - | [[Category: Lavoie, T | + | [[Category: Lavoie, T B.]] |
[[Category: Leytze, G.]] | [[Category: Leytze, G.]] | ||
| - | [[Category: Linsley, P | + | [[Category: Linsley, P S.]] |
| - | [[Category: Metzler, W | + | [[Category: Metzler, W J.]] |
[[Category: Mueller, L.]] | [[Category: Mueller, L.]] | ||
[[Category: Naemura, J.]] | [[Category: Naemura, J.]] | ||
[[Category: Peach, R.]] | [[Category: Peach, R.]] | ||
| - | [[Category: Shaw, S | + | [[Category: Shaw, S Y.]] |
[[Category: immune response]] | [[Category: immune response]] | ||
[[Category: immunoglobulin]] | [[Category: immunoglobulin]] | ||
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[[Category: t cell receptor]] | [[Category: t cell receptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:44:26 2008'' |
Revision as of 09:44, 21 February 2008
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CTLA-4, NMR, 20 STRUCTURES
Overview
The structure of human CTLA-4 reveals that residues Met 99, Tyr 100 and Tyr 104 of the M99YPPPY104 motif are adjacent to a patch of charged surface residues on the A'GFCC' face of the protein. Mutation of these residues, which are conserved in the CTLA-4/CD28 family, significantly reduces binding to CD80 and/or CD86, implicating this patch as a ligand binding site.
About this Structure
1AH1 is a Single protein structure of sequence from Homo sapiens. Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28., Metzler WJ, Bajorath J, Fenderson W, Shaw SY, Constantine KL, Naemura J, Leytze G, Peach RJ, Lavoie TB, Mueller L, Linsley PS, Nat Struct Biol. 1997 Jul;4(7):527-31. PMID:9228944
Page seeded by OCA on Thu Feb 21 11:44:26 2008
