2wgx
From Proteopedia
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===HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D=== | ===HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D=== | ||
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Revision as of 10:47, 25 July 2012
Contents |
HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D
Template:ABSTRACT PUBMED 19515728
About this Structure
2wgx is a 2 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Khoo KH, Joerger AC, Freund SM, Fersht AR. Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core. Protein Eng Des Sel. 2009 Jul;22(7):421-30. Epub 2009 Jun 10. PMID:19515728 doi:10.1093/protein/gzp018
- Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
Categories: Homo sapiens | Fersht, A R. | Joerger, A C. | Khoo, K H. | Apoptosis | Cancer | Cell cycle | Dna-binding domain | Dna-binding protein | Li-fraumeni syndrome | Metal binding | Nuclear protein | Nucleus | P53 | P63 | P73 | Protein stabilization | Second-site suppressor mutation | Superstable mutant | Transcription regulation | Tumor suppressor
