1w2y
From Proteopedia
(New page: 200px<br /> <applet load="1w2y" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w2y, resolution 1.65Å" /> '''THE CRYSTAL STRUCTU...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W2Y is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]] with MG and DUN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W2Y OCA]]. | + | 1W2Y is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]] with MG and DUN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W2Y OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Campylobacter jejuni]] | [[Category: Campylobacter jejuni]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: dUTP diphosphatase]] | ||
[[Category: Galperin, M.Y.]] | [[Category: Galperin, M.Y.]] | ||
[[Category: Gonzalez-Pacanowska, D.]] | [[Category: Gonzalez-Pacanowska, D.]] | ||
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[[Category: pathogen]] | [[Category: pathogen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:33:27 2007'' |
Revision as of 11:28, 30 October 2007
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THE CRYSTAL STRUCTURE OF A COMPLEX OF CAMPYLOBACTER JEJUNI DUTPASE WITH SUBSTRATE ANALOGUE DUPNHP
Overview
The crystal structure of the dUTPase from the important gastric pathogen, Campylobacter jejuni has been solved at 1.65 A spacing. This essential, bacterial enzyme is the second representative of the new family of dimeric, dUTPases to be structurally characterised. Members of this family have a, novel all-alpha fold and are unrelated to the all-beta dUTPases of the, majority of organisms including eukaryotes such as humans, bacteria such, as Escherichia coli, archaea like Methanococcus jannaschii and animal, viruses. Therefore, dimeric dUTPases can be considered as candidate drug, targets. The X-ray structure of the C.jejuni dUTPase in complex with the, non-hydrolysable substrate analogue dUpNHp allows us to define the, positions of three catalytically significant phosphate-binding ... [(full description)]
About this Structure
1W2Y is a [Single protein] structure of sequence from [Campylobacter jejuni] with MG and DUN as [ligands]. Active as [dUTP diphosphatase], with EC number [3.6.1.23]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases., Moroz OV, Harkiolaki M, Galperin MY, Vagin AA, Gonzalez-Pacanowska D, Wilson KS, J Mol Biol. 2004 Oct 1;342(5):1583-97. PMID:15364583
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