3bhv

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[[Image:3bhv.png|left|200px]]
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{{STRUCTURE_3bhv| PDB=3bhv | SCENE= }}
{{STRUCTURE_3bhv| PDB=3bhv | SCENE= }}
===Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B===
===Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B===
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{{ABSTRACT_PUBMED_17804748}}
{{ABSTRACT_PUBMED_17804748}}
==About this Structure==
==About this Structure==
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3BHV is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BHV OCA].
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[[3bhv]] is a 4 chain structure of [[Cell Division Protein Kinase 2]] and [[Cyclin]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BHV OCA].
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==See Also==
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*[[Cell Division Protein Kinase 2|Cell Division Protein Kinase 2]]
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*[[Cyclin|Cyclin]]
==Reference==
==Reference==
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<ref group="xtra">PMID:17804748</ref><references group="xtra"/>
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<ref group="xtra">PMID:017804748</ref><ref group="xtra">PMID:018232649</ref><references group="xtra"/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
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[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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[[Category: Polymorphism]]
 
[[Category: Ser/thr protein kinase]]
[[Category: Ser/thr protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:01:40 2009''
 

Revision as of 11:26, 25 July 2012

Image:3bhv.png

Template:STRUCTURE 3bhv

Contents

Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B

Template:ABSTRACT PUBMED 17804748

About this Structure

3bhv is a 4 chain structure of Cell Division Protein Kinase 2 and Cyclin with sequence from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Bettayeb K, Tirado OM, Marionneau-Lambot S, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drueckes P, Schachtele C, Kubbutat MH, Liger F, Marquet B, Joseph B, Echalier A, Endicott JA, Notario V, Meijer L. Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. Cancer Res. 2007 Sep 1;67(17):8325-34. PMID:17804748 doi:67/17/8325
  • Echalier A, Bettayeb K, Ferandin Y, Lozach O, Clement M, Valette A, Liger F, Marquet B, Morris JC, Endicott JA, Joseph B, Meijer L. Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex. J Med Chem. 2008 Feb 28;51(4):737-51. Epub 2008 Jan 31. PMID:18232649 doi:10.1021/jm700940h

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