1w29
From Proteopedia
(New page: 200px<br /> <applet load="1w29" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w29, resolution 2.30Å" /> '''LUMAZINE SYNTHASE F...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W29 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with K, TS1, TS0, D1D and ACY as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W29 OCA]]. | + | 1W29 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with K, TS1, TS0, D1D and ACY as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W29 OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors., Morgunova E, Meining W, Illarionov B, Haase I, Jin G, Bacher A, Cushman M, Fischer M, Ladenstein R, Biochemistry. 2005 Mar 1;44(8):2746-58. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15723519 15723519] | Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors., Morgunova E, Meining W, Illarionov B, Haase I, Jin G, Bacher A, Cushman M, Fischer M, Ladenstein R, Biochemistry. 2005 Mar 1;44(8):2746-58. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15723519 15723519] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Riboflavin synthase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bacher, A.]] | [[Category: Bacher, A.]] | ||
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[[Category: x-ray diffraction]] | [[Category: x-ray diffraction]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:34:39 2007'' |
Revision as of 11:29, 30 October 2007
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LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7-TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) BUTANE 1-PHOSPHATE
Overview
The enzymes involved in the biosynthesis of riboflavin represent, attractive targets for the development of drugs against bacterial, pathogens, because the inhibitors of these enzymes are not likely to, interfere with enzymes of the mammalian metabolism. Lumazine synthase, catalyzes the penultimate step in the riboflavin biosynthesis pathway. A, number of substituted purinetrione compounds represent a new class of, highly specific inhibitors of lumazine synthase from Mycobacterium, tuberculosis. To develop potent antibiotics for the treatment of, tuberculosis, we have determined the structure of lumazine synthase from, M. tuberculosis in complex with two purinetrione inhibitors and have, studied binding via isothermal titration calorimetry. The structures were, determined by molecular ... [(full description)]
About this Structure
1W29 is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with K, TS1, TS0, D1D and ACY as [ligands]. Active as [Riboflavin synthase], with EC number [2.5.1.9]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors., Morgunova E, Meining W, Illarionov B, Haase I, Jin G, Bacher A, Cushman M, Fischer M, Ladenstein R, Biochemistry. 2005 Mar 1;44(8):2746-58. PMID:15723519
Page seeded by OCA on Tue Oct 30 13:34:39 2007
Categories: Mycobacterium tuberculosis | Riboflavin synthase | Single protein | Bacher, A. | Cushman, M. | Fischer, M. | Haase, I. | Illarionov, B. | Ladenstein, R. | Meining, W. | Morgunova, E. | ACY | D1D | K | TS0 | TS1 | Crystal structure | Inhibitor binding | Lumazine synthase | Riboflavin biosynthesis | Transferase | X-ray diffraction
